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Cancer is a disease of runaway cell proliferation. Normally, a variety of genes coordinate to keep cell growth under control and on track. If a gene goes awry at any step in the cell cycle, another can compensate to keep cancer from developing. Now researchers at the University of North Carolina at Chapel Hill School of Medicine and UNC Lineberger Comprehensive Cancer Center have found that defects in one gene called p18 may override all the rest, eventually leading to breast cancer.
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