New Research On Vascular Endothelial Growth Factor From Brain Tumor Center Summarized

NewsRx.com

October 8, 2009

According to a study from the United States, "Preclinical studies suggest that inhibition of vascular endothelial growth factor (VEGF) improves glioma response to radiotherapy. Bevacizumab, a monoclonal antibody against VEGF, has shown promise in recurrent gliomas, but the safety and efficacy of concurrent bevacizumab with brain irradiation has not been extensively studied."

"The objectives of this study were to determine the safety and activity of this combination in malignant gliomas. After prior treatment with standard radiation therapy patients with recurrent glioblastoma (GBM) and anaplastic gliomas (AG) received bevacizumab (10 mg/kg intravenous) every 2 weeks of 28-day cycles until tumor progression. also received 30 Gy of hypofractionated stereotactic radiotherapy (HFSRT) in five fractions after the first cycle of bevacizumab. Twenty-five patients (20 GBM, 5 AG; median age 56 years; median Karnofsky Performance Status 90) received a median of seven cycles of bevacizumab. One patient did not undergo HFSRT because overlap with prior radiotherapy would exceed the safe dose allowed to the optic chiasm. Three patients discontinued treatment because of Grade 3 central nervous system intratumoral hemorrhage, wound dehiscence, and bowel perforation. Other non-hematologic and hematologic toxicities were transient. No radiation necrosis was seen in these previously irradiated patients. For the GBM cohort, overall response rate was 50%, 6-month progression-free survival was 65%; median overall survival was 12.5 months, and 1-year survival was 54%. Bevacizumab with HFSRT is safe and well tolerated," wrote P.H. Gutin and colleagues, Brain Tumor Center.

The researchers concluded: "Radiographic responses, duration of disease control, and survival suggest that this regimen is active in recurrent malignant glioma."

Gutin and colleagues published their study in International Journal of Radiation Oncology Biology Physics (SAFETY AND EFFICACY OF BEVACIZUMAB WITH HYPOFRACTIONATED STEREOTACTIC IRRADIATION FOR RECURRENT MALIGNANT GLIOMAS. International Journal of Radiation Oncology Biology Physics, 2009;75(1):156-163).

For more information, contact P.H. Gutin, Mem Sloan Kettering Cancer Center, Dept. of Neurosurgery, Brain Tumor Center, 1275 York Avenue, New York City, NY 10065, USA.

Publisher contact information for the International Journal of Radiation Oncology Biology Physics is: Elsevier Science Inc., 360 Park Avenue South, New York, NY 10010-1710, USA.

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