Studies From University Of Texas Have Provided New Data On Large-cell Lymphoma

NewsRx.com

October 15, 2009

According to recent research from the United States, "Context.-Lymphomas involving the breast are rare, and most cases are of B-cell lineage; T-cell neoplasms represent less than 10% of all breast lymphomas. Objective.-To define the clinicopathologic spectrum of anaplastic large cell lymphomas (ALCLs) involving the breast."

"Design.-Six cases of ALCL involving the breast were identified at a single institution during 21 years. The clinicopathologic and immunophenotypic features are presented, and the literature is reviewed. Results.-All patients were women, with a median age of 52 years. There were 4 anaplastic lymphoma kinase negative (ALK(-)) ALCL cases; 3 of these neoplasms developed around breast implants. Two patients with ALK(-) ALCL had a history of cutaneous ALCL. There were 2 ALK(-) ALCLs; both patients had stage IV disease. Histologically, all neoplasms were composed of large anaplastic cells that were uniformly CD30(+) and expressed markers of T-cell lineage. Four patients with adequate follow-up are alive, with a mean of 4.1 years (range, 1.5-9 years) after diagnosis of the breast tumor. Included in this group are 2 patients with ALK(-) ALCL associated with breast implants who were alive 4 years and 9 years after diagnosis. Conclusions.-Including the 6 cases we describe, a total of 21 cases of ALCL involving the breast are reported. Fifteen cases, all ALK(-), were associated with breast implants, suggesting a possible pathogenetic relationship, and associated with an excellent prognosis," wrote R.N. Miranda and colleagues, University of Texas (see also Large-Cell Lymphoma).

The researchers concluded: "With cutaneous ALCL can subsequently develop ALK(-) ALCL involving the breast, and these tumors can be associated with breast implants. (Arch Pathol Lab Med. 2009; 133:1383-1390)."

Miranda and colleagues published their study in Archives of Pathology & Laboratory Medicine (Anaplastic Large Cell Lymphoma Involving the Breast A Clinicopathologic Study of 6 Cases and Review of the Literature. Archives of Pathology & Laboratory Medicine, 2009;133(9):1383-1390).

For additional information, contact R.N. Miranda, University of Texas MD Anderson Cancer Center, Dept. of Hematopathol, Unit 072, 1515 Holcombe Blvd., Houston, TX 77030, USA.

Publisher contact information for the journal Archives of Pathology & Laboratory Medicine is: College American Pathologists, C, O Kimberly Gacki, 325 Waukegan Rd., Northfield, IL 60093-2750, USA.

Keywords: United States, Houston, Anaplastic Large Cell Lymphoma, Breast Implants, Cancer, Enzyme Research, Hematology, Kinase, Large-Cell Lymphoma, Medical Device, Neoplasms, Oncology, Pathology, Women's Health, University of Texas.

This article was prepared by Proteomics Weekly editors from staff and other reports. Copyright 2009, Proteomics Weekly via NewsRx.com.

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