But many high-risk women who should get scanned don't, experts add
THURSDAY, June 13 (HealthDay News) -- Newly identified genetic variations may help predict which women will respond to breast cancer prevention therapy, a new study suggests.
By determining who would and would not receive possible benefit from two preventive drugs, women who aren't likely to respond could be spared the treatment and its side effects, the study authors noted.
Researchers examined data on women enrolled in two large breast cancer prevention trials, including 592 women who had developed cancer along with 1,171 similar women who did not.
The investigators found that women with a favorable genetic variation (called a "single nucleotide polymorphism" or SNP) in the gene ZNF423 and another near the gene CTSO were more likely to respond to prevention therapy with tamoxifen and raloxifene.
Women with unfavorable variations of these SNPs may not benefit from prevention therapy and have a five-fold increased risk of developing breast cancer, according to the study published June 13 in the journal Cancer Discovery.
"The recent guidelines by the U.S. Preventive Services Task Force emphasize that ... therapy with tamoxifen and raloxifene can lower a woman's risk for developing breast cancer. But about 50 women have to be exposed to the treatment and side effects to prevent a single case of breast cancer," study author Dr. James Ingle, a professor of oncology at the Mayo Clinic in Rochester, Minn., said in a journal news release.
"Our findings are important, because for the first time, we discovered genetic factors that could be used to select women who should be offered the drugs for prevention. Also of substantial importance is that we have discovered new information on how tamoxifen and raloxifene work to prevent breast cancer," he added.
"Findings from our study provide clear direction as to which women are likely and which are unlikely to benefit from tamoxifen or raloxifene," Ingle explained. "The best chance we have of decreasing the burden of breast cancer is to prevent it in the first place. Our findings provide the basis for a reinvigoration of research efforts in breast cancer prevention."
The U.S. National Cancer Institute has more about breast cancer prevention.
SOURCE: Cancer Discovery, news release, June 13, 2013
Copyright © 2013 HealthDay. All rights reserved.
Wed Jun 19, 2013 09:21 PM
I can answer this one easily... NONE would benefits from drugs for breast cancer prevention. ALL would be healed if they used cannabis... and it appears NOT thc, but CBD-cannabidiol along with possibly CBN, THCa, CBDa will eliminate breast and many cancers. Realize that CBD is without any psychoactive effect, just cures.
Tue Jun 25, 2013 01:59 PM
@GnoMad56 - how do you know this? Please explain how you know about canabis...what are the differences. I am a breast cancer survivor x 2 years. Still can't get past the angera about...I've had quite a few difficulties in my life to deal with and this was like throwing salt on an open wound. At any rate, I went through theuglychemo, 37 radiation treatments, and a complete year of Herceptin. The herceptin left me with bone, joint, and muscular pain...sometimes unbearable. All of that for a stage I tumor, albeit 2 types of breast cancer. I also happen to be triple positive. I worry that it will come back. So...I am very interested in your knowledge. Especially since I met a neonatologist that was being treated for a neuroblastoma (she eventually succumbed to the tumor and passed away a few months ago) who said there already is a cure for ALL cancer. The problem is that this country has become so money hungry, and cancer is aHUGEmoney maker...drugs, treatment, etc. The herceptin treatments alone totalled approximately $225,000...1 treatment every 3 weeks for 1 year. Ridiculous and so unfair if that is the truth. Please share your info and insight. Thanks.
Fri Jun 28, 2013 06:15 PM
@shaunmattox email me and I'll send you some info. NOT
on the Cannabis - I don't know anything about that. I just
had my stage one journey too !
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