Could Daughter's Cancer Risk Be Affected by Father's Age at Birth?

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Early study tied younger dads to higher odds of breast, ovarian tumors, and older dads to increased risk of uterine diseaseTUESDAY, April 8, 2014 (HealthDay News) -- A father's age at the time of his daughter's birth may affect her risk for breast, ovarian and endometrial cancer in adulthood, a new study suggests.

Researchers examined data from more than 133,000 women who took part in a study of California teachers and administrators. Between 1995 and 2010, more than 5,300 of the women were diagnosed with breast cancer, 515 with ovarian cancer and more than 1,100 with endometrial cancer -- cancer of the lining of the uterus.

Compared to women born to fathers aged 25 to 29, those born to fathers younger than age 20 were 35 percent more likely to develop breast cancer and nearly two times more likely to develop ovarian cancer.

On the other hand, those born to fathers aged 30 to 34 had a 25 percent higher risk of endometrial cancer.

The study was scheduled for presentation Monday at the American Association for Cancer Research (AACR) annual meeting, held in San Diego. Studies should be viewed as preliminary until published in a peer-reviewed journal.

Previous research has looked at how parents' age at the time of birth affects a child's health. But few have focused on the link between parents' age and a daughter's risk of these three hormone-related cancers in adulthood, according to the City of Hope researchers.

"Our findings indicate that parental age, especially paternal age, at conception appears to be associated with a wide range of effects on the health and development of the offspring," study leader Yani Lu said in an AACR news release.

While the study found a connection between a daughter's risk of cancer and her father's age when she was born, it did not establish a cause-and-effect relationship.

More information

The U.S. Centers for Disease Control and Prevention has more about women and cancer.

SOURCE: American Association for Cancer Research, news release, April 7, 2014

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Thu Apr 10, 2014 05:33 AM

A father's age! I was expecting to read about Fathers who were at least 50 plus! I have recently been diagnosed with breast cancer which is now in my lymph nodes and there are some suspicious dots on my lungs. It is a very aggressive cancer. My Dad was 54 when I was born. Maybe you should study that!

Sat Apr 12, 2014 12:06 PM

my father was forty when I was born - so far I am a healthy woman of 65 - I hope I will not be a statistic unless it is a positive one. 

My husband died of colon cancer - however he was healthy most of his life -

I think there is too much emphasis on statistics ---

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