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Mgus

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Subject: MGUS
Date: 06/14/2007

Hi, everyone.

I too have a mgus. I have done much research because I was sent to a doctor without being told why I was going or what to expect. MGUS  stands for monoclonal gammapathy of unspecified significance. It has to do with white blood cells, plasma cells, that are without use to the body because they are cloned and not produced by the bone marrow. There is also the 'M' protein that clogs up the blood. There are basically 3 kinds of MGUS.  If these two components become too much, they can cause problems in the kidneys and other organs. MGUS is associated with a syndrome called POEMS, the M being for the mgus. The mgus can become malignant. Usually after the age of 62 if at all. It is a rare disease, they say and POEMS is discussed by NORD, the organization for rare diseases. The P is for polyneuropathy, which can cause tingling, numbing, etc., O for organomegly (sp may not be exact, but it is organ enlargement), E for endocrine problems such as diabetes and the S is for skin problems such as thickening and dryness as well as excessive hair growth. IF you go to the NORD website and plug in  POEMS or even now there are sites that discuss MGUS, unlike when I was first diagnosed, they have quite a bit of information. If your doctor sends you to an oncologist/hematologist and he sees you once a year, that is all to be expected unless he finds cause for concern. IF and I do mean IF, you develop the other symptoms of the POEMS syndrome, you need more skilled assistance to help with the symptoms. I have POEMS. Many days are bad. Some not so much. All of you with MGUS: hang in there and try to see the sunshine. It could be much worse..Just reading the other messages of people with cancer makes me know I'm not so bad off after all.

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