The personality changes are the hardest thing of all to cope with when you already are grief stricken and so worried about someone. I keep telling myself that it is not really my mom talking or behaving certain difficult ways, but the chemotherapy and medications and stress and physical fatigue and sickness...
My moms personality changed so drastically after her original surgery that all of us family could only scratch our heads (and cry) in bewilderment. We thought maybe she had a stroke during the surgery because she was like a stranger. I really think that this component of the chemotherapy/surgery/disease should be more thoroughly studied and explained to caregivers and family members as it is so very difficult and painful for everyone.
My mom is more back to her old self after one year and the end of the first round of chemo...thank-god....I cherish these calmer times.
Losing someone to cancer is 1000 times more unbearable with these personality difficulties....just try to bear thru it and not take anything personal and be there for them as best as you can. I know it is just so very very hard. Remember them as they truly were.
Medication for the personality I know nothing about. God bless you.