My mom has stage IV endometrial cancer, adenocarcinoma, mets to lungs and bones. She tried 2 cycles of carbo/taxol but it didn't help much. She has been on megace since mid April and her scans in June and again at the beginning of Aug show the cancer is decreasing, especially in the lungs. We are so happy about these results. The side effect is weight gain, and my mom has gained a little weight. She also noticed some shortness of breathe at times since beginning the megace. Otherwise, we are happy this drug is shrinking and controlling the cancer.