I'm sorry to hear about your sister's diagnosis. To answer your questions, yes, I believe there are cases which have spread to the bones and the liver counts increase are probably the bilirubin and liver enzymes (alk phos...). This typically means that there is some sort of obstruction where the bile cannot drain properly. An ERCP is a procedure that a GI dr will do where they can go through the mouth and put a stent in the place where the obstruction is. For some cases, they need to do a PTC which is a catheter procedure that is threaded into the obstruction by an interventional radiologist. In either case, you should ask if either of these are a possibility. Make sure you get more than 1 opinion.
Visit www.cholangiocarcinoma.org and there are many patients and caregivers who share their experiences and answer questions. Your sister and your family are in my prayers.