My husband received one treatment of Methotrexate in June. It was too hard on his kidneys so the doctor put it on the back burner as a last resort. He then put him on 4 treatments of Rituxin. We do not know yet if the Rituxin worked, but there was significant shrinkage of the brain tumors after one dose of Methotrexate.
Next step if Rituxin did not work is Temolozide, a pill form of chemotherapy. Doctor said to hold off on radiation as long as possible because it could cause problems down the road like about 3 years or more. He also said some people do not experience any future problems after radiation.
Did your daughter-in-law ever get more Methotrexate? How is she doing?