I was diagnosed with RCC Stage 3B in Oct. 2005. I went on Nexavar in November 2005 after my Nephrectomy. I could only take Nexavar for three months before the lymph nodes started to enlarge, then I moved on to Sutent. I took Sutent and had minor side effects, but it kept me stable for 18 months. No issues with the transition. Sutent was much more tolerable for me. After 18 months on Sutent, I developed "Pleural Effusions" (fluid buildup in the lining of my left lung), so my oncologist has moved me to a more aggressive Chemo treatment. I now take Xeloda, Gemzar, and Avastin. All stable now.
I hope the Sutent works well for you.
D. J.