I can understand your concern and by the way, you can't be Gleason 7-8. It was either 7=3+4, 7=4+3 or 8=4+4. Depending on which one it was is truly a significant fact to know and understand. Regarding your specific question, I can't tell you that I have had that specific experience but if it's any comfort to you I know a well known prostate cancer doctor who has been on intermittent ADT for more than 25 years. Check out the charts in Strum's book showing the results of patients on ADT. They should be comforting to you. I think that you are doing the right thing to be aggressive in pursuing this. 0.2 isn't extremely high and doubling time is an important measure to determine (have you done that?). As I suggest to everyone who is at a decision point, I'd suggest that you contact one of the handful of prostate cancer experts who I've suggested over and over on these boards. Doctors like Strum, Scholz, Myers, Small, Logothetis, and Raghavan (and a few others) can discuss the absolute state of the art tests / therapies with you. You'll need to provide them with a detailed digest. My best wishes to you.