Doxil And Velcade ??????

My sister Denys might be put on Doxil in combination with the Velcade. 

She also spoke to me about her Dr. mentioning Revilimid and Velcade together sometime down the line? She has developed the Myeloma in both Tibia's in her legs,groin area, and a mass in her pelvis. This is giving her extreme pain to say the least.  She also has a tumor of some sort on her back about the size of an egg  will require a biopsy in a week or two..  She has begun 15 weeks of radiation cramed into 5 days because  Dr. Hassiani at Moffit in Tampa doesn't want her off Chemo that long.

Has anyone been on Doxil with their Velcade or know of someone who is???

Thanks Susan

 

 

On 12/22/2007 Bayshore wrote:

My sister Denys might be put on Doxil in combination with the Velcade. 

She also spoke to me about her Dr. mentioning Revilimid and Velcade together sometime down the line? She has developed the Myeloma in both Tibia's in her legs,groin area, and a mass in her pelvis. This is giving her extreme pain to say the least.  She also has a tumor of some sort on her back about the size of an egg  will require a biopsy in a week or two..  She has begun 15 weeks of radiation cramed into 5 days because  Dr. Hassiani at Moffit in Tampa doesn't want her off Chemo that long.

Has anyone been on Doxil with their Velcade or know of someone who is???

Thanks Susan

 

I am not familiar with Doxil, but the combination of Velcade/Revlimid/Dex (which appears to be where the doctor is headed) has shown very promising results in clinical trials.

The very best to you and your family.

Craig 

 

I am currently on Doxil w/o Dex or Velcade. The dex has weakened my leg muscles severely so we are giving it a break so maybe my muscles will recover. Doxil drove my white blood count down to 2000. It too had to be stopped for two months. It has to be a minimum of 3000 before my dr will give me any more. My hands blistered from the doxil. They tell you no sunlight and THEY MEAN IT!. Also just friction on your hands can cause blistering. My hands completely peeled just like they had been sunburned. Lotion, lotion, and more lotion. Whatever they give you at the dr's USE IT My feet never blistered but they got tender and still are. I was told that doxil originally was for ovarian cancer. So far I am not too pleased with doxil. The two months I haven't been given any chemo my cancer has probably gotten worse. Poppy

 

On 12/28/2007 Poppy 1952 wrote:

I am currently on Doxil w/o Dex or Velcade. The dex has weakened my leg muscles severely so we are giving it a break so maybe my muscles will recover. Doxil drove my white blood count down to 2000. It too had to be stopped for two months. It has to be a minimum of 3000 before my dr will give me any more. My hands blistered from the doxil. They tell you no sunlight and THEY MEAN IT!. Also just friction on your hands can cause blistering. My hands completely peeled just like they had been sunburned. Lotion, lotion, and more lotion. Whatever they give you at the dr's USE IT My feet never blistered but they got tender and still are. I was told that doxil originally was for ovarian cancer. So far I am not too pleased with doxil. The two months I haven't been given any chemo my cancer has probably gotten worse. Poppy

Hi Poppy,

I think we spoke before.  My sister Denys is not having much luck at all with her Myeloma.  She just had 3 weeks of radiation crammed into a 5 day period because her Dr. doesn't want her off the chemo that long. Her Myeloma has gone into her Pelvis and formed a  formed a plasmacytosis , Myleloma was also found in her Groin area, and both Tibias' during the extensive MRI she underwent.  She also has a 2 lumps on her back.  The first one was the size of an egg and has grown even with the radiation.  She just found the second which is small yet.  Her Dr. feels they are from the Myeloma.  She is waiting on pins and needles to have them biopsied.  She will be starting the Velcade along with Doxil and a bone builder  sometime next week.  I am very worried about her and afraid.  She is in extreme pain in her legs and obviously is fearful of the unknown .  Deny is supposed to go back to Little Rock for a bone marrow biospy to see if the Velcade has worked and if her Myeloma has gotten worse.  It is awful how my sister is suffering . I know from reading your posts that you have had rough times yourself.  When I read your posts you remind me of my sister , both of you share the same strength and courage.  Denys turned 55yrs old in July. I don't want to tell her about bad possible side effects from the Doxil.  She is trying to remain optimistic, she isn't ready to die, and she will fight to the end.  My sister is truly amazing in that sense.  Poppy she is so afraid, I love her very much..and would do anything for her.

Below is a piece of a letter she recently to sent me it reads as follows

 

In the meantime, last night I found another lump on my back. It is small, there none-the-less. I will give Al Hassani a call and find out if this can be biopsied now or whether I need to wait till the radiation is completely finished. I can only pray that they are benign. My heart is breaking, and it is as if the Myeloma is trying to cut me down. It Won't!! I may cry, but I will not let it take my soul!!!

 

 

 

Susan, You just don't know how it breaks my heart read your letters. I wish now I had never written those negative things about Doxil. I certainly don't want Denys reading them. Ya'll are in my prayers, that's about all I can do. You know I run into people I know all of the time that say "We are praying for you". My answer is "Don't Stop!".  Everyone of us who has MM relys on the hopes and prayers of those closest to us. My rock to lean on is my wife Shirley. God knows how much I love her and depend on her. Your sister feels the same about you. But sometimes the rock that's being leaned on needs uplifting, too. So this is yours. No one hates having this disease any more than me or Denys, but we are so glad we have our "Rocks" walking with us. God Bless you. Hugs to both of you. Poppy

 

On 12/29/2007 Poppy 1952 wrote:

Susan, You just don't know how it breaks my heart read your letters. I wish now I had never written those negative things about Doxil. I certainly don't want Denys reading them. Ya'll are in my prayers, that's about all I can do. You know I run into people I know all of the time that say "We are praying for you". My answer is "Don't Stop!".  Everyone of us who has MM relys on the hopes and prayers of those closest to us. My rock to lean on is my wife Shirley. God knows how much I love her and depend on her. Your sister feels the same about you. But sometimes the rock that's being leaned on needs uplifting, too. So this is yours. No one hates having this disease any more than me or Denys, but we are so glad we have our "Rocks" walking with us. God Bless you. Hugs to both of you. Poppy

Poppy,

Denys went to the emergency room yesterday.. The pain in her leg became unbearable.  The oxycotton was doing nothing to ease it at all.

I told her along with other friends and family to go to the hospital.  Her Dr. was supposed to be heading their last night. (Saturday).  I  know the the hospital will  start a morphine drip to control the pain.  This will help untill they get her back on the chemo.  She told me yesterday that the Velcade/Doxil were on order and they were just waiting for them to come in, then she would start.

While she is in there I think they will biopsy the lumps on her back, and maybe she would be better having the bone marrow biospy done now instead of waiting till the end of January to do it in Little Rock.  I booked our parents on a flight to Tampa for Saturday the 5Th. Denys is the oldest of six children , I am in the middle .  Our parents are both 78yrs old but you would never know it by looking at them.  . This year and a half has been a  huge rollar coaster with more downs.then ups. 

 I will never give up nor will my sister..  My parents will go down first, and then I will take if from there.  I am not married , self supportive and have a full time job..  Last year my job granted me leave to take care of my sister.  I was her caregiver for the Stem Cell Transplant and when she began the Velcade in Little Rock.  Since it was leave I didn't get paid so my Dad paid me my salary to help my sister. I really need to see how things pan out when my parents go before I book my own flight.

Thanks for the chat, it is always good to speak to somone else who understands things such as yourself.  How have you been doing and feeling lately?? Are you on any chemo?

Talk to you soon,

Susan

Susan

You know our prayers are with you. Little Rock is only about 280 miles from my huse in Tyler, Texas. I've often thought of visiting them. My dr has always told me that any time I wanted to go there or MD Anderson he would get me an appointment. He has no problem with another opinion. But I am confidant in him so far. I hope to be a transplant candidate myself someday. Keep us posted. Love ya, Poppy