Hi-So sorry things aren't going well. We have used domperidone for awhile and the effects were noticeable quickly, but I don't think the reflux was anywhere near as bad or frequent as your husband. We have also found some relief with a homeopathic remedy called Acidil to treat acid although not so much for reflux, but maybe if you could get the acid down the reflux would be less. Seems to me that once the cycle starts, it's hard to knock back down to manageable, so maybe it will just take a bit of time for things to settle down. My husband is having a bit more reflux at the moment, but it's slight and he's not aspirating it, thank God! He had an emergency small bowel resection two weeks back, so I'm wondering if the increase is related to the surgery, and will be better soon. I always recommend tongren for people open to energy healing. It could help with the reflux, depression, or keeping future cancer at bay. It is also a great immune system builder. We all have up to 3 wishes per session, and they do conference phone calls regularly for people who are not near any of the groups who meet. You can find info on it at tongrenworld.com. Good luck with your husband. Will keep you both in my prayers.