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What Is Psa Doubling Exactly?

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Subject: what is psa doubling exactly?
Date: 02/11/2008
I'm not sure on my case. I was diaagnosed with prostate cancer Mar. 2007 had 4.2 psa and glleason score 3+4=7 had R.P. April 07 and my first psa after R.P. was .01  in July 2007 -- .05  in Oct. 2007 and 1.0 in Jan. 2008, would these  numbers be concidered doubling and if so what's my next move, the Doctor say's  to check it again in 3 months, Thanks Gary
Doctor / Nurse
Doctor / Nurse
Oncrx
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Subject: RE: what is psa doubling exactly?
Date: 02/12/2008
PSA doubling is the amount of time it takes for your PSA to double.   Most would say patients with a doubling time of three to 12 months are at a significant risk for the development of systematic disease.   Since you had a RP your PSA should be 0.  You have residual disease and I would want to be more agressive than a repeat PSA.
Subject: RE: what is psa doubling exactly?
Date: 02/12/2008
Thanks, for the info, I've learned a lot just reading on this site, Gary
Subject: RE: what is psa doubling exactly?
Date: 03/16/2008

Hi Gary,

Are you sure the January reading was 1.0 rather than 0.1? If so, then your PSA doubling time is less than a month -- extremely dangerous:
   07/2007 ... 0.01 (perhaps misread from "<0.01")
 (08/2007 ... 0.0069)

 (09/2007 ... 0.0185)


  10/2007 ... 0.05
 (11/2007 ... 0.136)
 (12/2007 ... 0.367)
  01/2008 ... 1.0 (calculated as an increase of 2.7 per month)
 

? 02/2008 ... 2.7 (projected, assuming an increase of 2.7 per month)
 


? 03/2008 ... 7.3 (projected, assuming an increase of 2.7 per month)
 



? 04/2008 ... 20 (projected, assuming an increase of 2.7 per month)
 



? 05/2008 ... 53 (projected, assuming an increase of 2.7 per month)

Such an aggressive doubling rate is extremely rare, and so I suspect that some kind of miscommunication has taken place. But even if your January value was 0.1 rather than 1.0, it represents a three-month doubling time -- still quite worrisome.

 If it were me, I wouldn't wait another three months; I'd schedule a consultation with another medical oncologist as soon as possible.

/Paul in Los Angeles

 

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