Unfortunately, there is no cure for locally advanced pancreatic cancer.
Chemoradiation is often useful to prevent localized complications of the tumour, but does not extend life.
Chemotherapy can be tried for palliation of symptoms, and may prolong life a little (~6 months on average).
High dose melatonin (20 mg every evening) and fish oil (EPA) 2 g daily have been shown to slow down the almost universal weight loss associated with pancreatic cancer.