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Bevacizumab

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Subject: bevacizumab
Date: 03/04/2008
My Mother has Primary Peritoneal Carcinoma. Starting in Sep she was treated with Carboplatin and Taxol. She was also given a experimental drug called Bevacizumab. The treatment ended for the other 2 chemos in Jan but she continued on Beva. She was told in feb that for now she is cancer free. No sooner did she get that news that everything changed. She has lost her memory,cant even name her 4 children.She does the strangest things,mixes everything up. She can't walk without help. She has become a different person. She has had CAT scans, MRI and many other tests. No one can find anything. I read an article on drugs.com that said this drug can cause a rare neuro disease. Has anyone heard about this??? Has anyone had any experience like this??
Doctor / Nurse
Doctor / Nurse
Oncrx
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Subject: RE: bevacizumab
Date: 03/04/2008
 I suppose it possible.  Avastin has been associated with reversible posterior leukoencephalopathy syndrome (RPLS), a neurological disorder which can present with headache, seizure, lethargy, confusion, blindness, and other visual and neurologic disturbances.  It usually presents after a hypertensive episode.  Did she have any hypertension from the Avastin?
Subject: RE: bevacizumab
Date: 03/05/2008
No. My mother has never had high bllod pressure. My father took her to the emergency room Mon and she is still therer. They have run tests and brought in a Neurologist and cannot figure out what is wrong. No stroke, tumors etc show up on and MRI or CAT scan. She can't even stand now on her own. Her memeory is very bad. She knows you when you are with her and talks but cannot answer questions. He is running further tests but doesn't know what to think besides the chemo. Taxol, Carboplatin and the Beva. She was fine all through chemo and started this 3 weeks after the regular chemo ended and she had 2 treatments of Beva alone.I read Beva can cause a rare neuro. disease but cannot find any more information on wheater or not things like this are permanent.
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