Hi, I am taking Arimidex since Jan/05 and my oncologist has discovered it is not doing its job properly and I am still producing too much estrogen which for my aggressive cancer is bad news, so I was told to keep on with the Arimidex and started with Zoladex as of last week. That was quite the experience having the injections...large needle which inserts pellets the size of a grain of rice under the sub-cutaneous tissue of the stomach....ouch! I have not seen any posts about this drug here, so wondered if anybody else has experienced it and if so, what your side effects were? So far, I have not experienced hot flashes, but have been terribly fatigued - still one week after - and have bone pain, the worst is in my lower legs and lower arms, around the wrists. The fatigue feels like when I had the chemo...and I am dragging a heavy body around. Kind of flu-like symptoms but worse. It is hard to know if it is the Arimidex or the Zoladex or the combination of the two. Any insight would be appreciated.