Hi-Did not do clinical trial, but used some of these drugs. My husband's cocktail consisted of 1/wk infusion of cisplatin, irinotecan and docetaxol (some of the drugs are the same but may be called different things depending on Brand Name of manufacturer). We did 2 weeks on/1 off and 2 more on/1 off to make up a round of chemo (the off weeks are worse than on with side effects, which is why they give it off). Primary tumor was adenocarcinoma at esophagus/gastric junction, and mets to lung. Started with radiation/chemo-shrank primary and cleaned up lung mets-followed with Ivor-Lewis and lung resection (3 local lymph nodes positive, lung met negative-no follow up chemo). Second lung resection about 9 months later with small lung met positive for EC. 2 months later, mets to both lungs with two rounds of same chemo (no radiation, but bigger chemo drug doses-BRUTAL but still here). Finished chemo last May or June. NED up till December when he faced emergency bowel resection. 2-3 weeks after resection, mets back in both lungs. They fluctuate between growing slightly to others doing nothing at all. My belief is that his setbacks in the past few months have allowed the mets to get a foothold again, and the oncologist does not discount my theory. We do a form of energy healing called tongren, and I also believe it has helped us to keep the cancer at least somewhat at bay, and clearly made a difference in chemo side effects while in treatment. The chemo regimen is quite intense. The first round/radiation caused some hair loss, but the second round made every hair on his body depart within days, so I'd advise a short haircut so there's not a trail on pillows, showers, etc. The diarrhea from the irinotecan is worse than you could ever imagine, or was in our case. It went on for weeks, and involved a couple hospital stays for hydration, before I got really good at recognizing the danger signals and knew to get him hydrated before it was critical. Don't let the nausea or pain (if experiencing either) get ahead of you because it makes it very difficult to knock down. If you don't get results from anti-emetics prescribed, try another. We found the combination of Emend/zofran kept us from starting endless rounds of vomiting that went along with 1st round of chemo/radiation when we used just Zofran. Are you in clinical due to bone met, as opposed to real treatment where you know what they are doing for sure? Would someone else consider using proven regimen instead? The regimen we used has had the best statistics to date, but I recognize that different treatments are used for different cancers, etc, so maybe the clinical trial choice is the best option with bone mets.