Granulosa Cell Tumours - Chemotherapy?

I am scheduled for surgery on May 15th, 2008 to remove 1 large and 2 small Granulosa Cell Tumours. This is my third surgery for GCT - the first in 2002 with complete hysterectomy (1 tumour), a second surgery in January 2007 (4 large tumours), and now a third surgery.

No chemo prior to this as my Oncologist says that GCT appears to be resistant to treatment (both chemo and radiation). Because the tumours have returned so quickly this time, he is suggesting either bleomycin etoposide and platininum BEP or carboplatin and Taxol. The latter sounds less toxic .....

Just wondering if anyone out there has had treatment for GCTs (other than surgery), what combination, and what result ....

Thanks

On 5/1/2008 Gct2-brenda wrote:

I am scheduled for surgery on May 15th, 2008 to remove 1 large and 2 small Granulosa Cell Tumours. This is my third surgery for GCT - the first in 2002 with complete hysterectomy (1 tumour), a second surgery in January 2007 (4 large tumours), and now a third surgery.

No chemo prior to this as my Oncologist says that GCT appears to be resistant to treatment (both chemo and radiation). Because the tumours have returned so quickly this time, he is suggesting either bleomycin etoposide and platininum BEP or carboplatin and Taxol. The latter sounds less toxic .....

Just wondering if anyone out there has had treatment for GCTs (other than surgery), what combination, and what result ....

Thanks

Hi  I have not had chemo, however I have a question for you.  After your total hysterectomy and 2nd surgery ( or really Before)...what were your symptoms?  I had a totoal hys. this year and removed one tumor and hopefully I'll know what to pay attention to.  Prior to my diagnosis, I bled for a couple years pretty consistent, so with the hyst. I obviously wont bleed.  I'm sorry I cant offer an answer to your question.

Take care and God Bless you

SusieB 

On 5/5/2008 SusieB wrote:

 

On 5/1/2008 Gct2-brenda wrote:

I am scheduled for surgery on May 15th, 2008 to remove 1 large and 2 small Granulosa Cell Tumours. This is my third surgery for GCT - the first in 2002 with complete hysterectomy (1 tumour), a second surgery in January 2007 (4 large tumours), and now a third surgery.

No chemo prior to this as my Oncologist says that GCT appears to be resistant to treatment (both chemo and radiation). Because the tumours have returned so quickly this time, he is suggesting either bleomycin etoposide and platininum BEP or carboplatin and Taxol. The latter sounds less toxic .....

Just wondering if anyone out there has had treatment for GCTs (other than surgery), what combination, and what result ....

Thanks

Hi  I have not had chemo, however I have a question for you.  After your total hysterectomy and 2nd surgery ( or really Before)...what were your symptoms?  I had a totoal hys. this year and removed one tumor and hopefully I'll know what to pay attention to.  Prior to my diagnosis, I bled for a couple years pretty consistent, so with the hyst. I obviously wont bleed.  I'm sorry I cant offer an answer to your question.

Take care and God Bless you

SusieB 

Hi,

I also had surgery 6 weeks ago to remove a larger GCT that was cancerous. Luckily it did not spread.  I had a completer Hysterectomy and Lymph Nodes removed.

The only sigh I had before they spotted the tumor was wierd bleeding for a year or so too.  I am also curious what symtoms if any Brenda had with 3 surgerys now.

I am being told no Chemo is necessary and to have bld tests and a CT scan every 6 months.

Take care of yourself,

Patti

On 5/1/2008 Gct2-brenda wrote:

I am scheduled for surgery on May 15th, 2008 to remove 1 large and 2 small Granulosa Cell Tumours. This is my third surgery for GCT - the first in 2002 with complete hysterectomy (1 tumour), a second surgery in January 2007 (4 large tumours), and now a third surgery.

No chemo prior to this as my Oncologist says that GCT appears to be resistant to treatment (both chemo and radiation). Because the tumours have returned so quickly this time, he is suggesting either bleomycin etoposide and platininum BEP or carboplatin and Taxol. The latter sounds less toxic .....

Just wondering if anyone out there has had treatment for GCTs (other than surgery), what combination, and what result ....

Thanks

 

Hi Brenda--My name is Kathy-- I am a 5 year survivor of GCT.  I had a fantastic GYN.onc. in Clearwater, Fl. who removed a 35 pound tumor in 2003.  I lost about 60 pounds, and my hair.  I had the combination of bleomycin, etoposide and cisplatin for a 12 week course.  five days on and then two weeks rest.  They gave me Kytril and Zofran for the nausea and it worked fantastically for me.  The biggest side effect from the chemo is peripheral neuropathy in my hands and feet (they feel like pins and needles) but the neurologist has prescribed Lyrica for that and it works wonders.  I feel good enough to work part-time, and have a very rewarding life now.  I hope this helps.  Good luck on your surgery, and may you do as well as I did.  Please let me know what happens.  Kathy