My mother in law has stage IV melanoma. It just keeps appearing at different places in her body. The last PET scan showed a fading patch on the chest wall. She has been on Temadur for almost a year. At first she was told 3 months, then the doctors kept telling her month by month, for the first 6 months she tolerated the treatments very well. Now the side effects are more uncomfortable, more exhaustion, leg aches pains & charlie horses, Nausea & vomiting, she has trouble sleeping, and in general her quality of life is not what it use to be, she just turned 80. Believe me when I tell you she use to be a fire cat. She now says that she could be on the chemo for the rest of her life. Isn't that a little much? Doesn't it get to the point where the octor might say look we need to change treatments? Or just wait for her to say enough? Another thought. Will the melanoma get to the point where it becomes stronger than the Temadur.