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Loss Of Coordination W/Avastin, Temodar, Decadron

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Subject: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/16/2008

My father has been experiencing loss of coordination.  He now has a hard time getting out of bed or the chair.  He has trouble walking, memory, everything.  It has been getting worse over the last month.  It started off when he was tired and is now all of the time.  We are afraid to leave him alone or out of sight.  If he bends over he is going down.  He has had significant reduction of the original tumor mass as well as other sites.  We are confused here.  Any information would be appreciated. 

Thank you for your help!

Subject: RE: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/16/2008

How much decadron is he taking?

Has it been reduced recently?

Subject: RE: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/16/2008
Are his platelets ok?  Leg pain?  Avastin is known to cause blood clots in a few people.
Subject: RE: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/17/2008
He was reduced to 4mg now they have him back up to 6mg.  He had been reduced for a while though.  As of last night he is back up to 6mg.  I guess we'll see how that goes.  Personally, I think it is the bolus Temodar and Avastin combo.  Usually, he has them one week apart but the last time they were together.  Not sure.  Hopefully the Decadron will help.  He is getting very discouraged.  
Subject: RE: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/17/2008
Platelets are fine.  No leg pain.  Not sure what to think he sleeps a lot now too.  We are thinking bout maybe switching to the metronomic schedule for the Temodar to see if that helps.  We think it is the Temodar 380mg x 5dys. 
Caregiver
Caregiver
Hopeful Debra
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Subject: RE: Loss of coordination w/Avastin, Temodar, Decadron
Date: 06/20/2008

Have you had a recent MRI? Just make sure, My dad had no results with Temadar and Avastin and Cpt 11.

Debra

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