Yeah my wife has stage IV ovarian cancer.Right now she is about 70lbs,and has tumors everywhere from her diaphragm,to her lymph nodes..and yes edema has set in,to her intestines,and liver,and also lungs which have to be tapped once a week.But we found a solution for her fatigue about 1 year ago,that I thought I would share with the rest of you.She takes Adderall which is used for ADD. It is speed,but since it is not abused there is no problem.It doesn't interfere with the dilodid she is on..nothing serious.It allows her to be awake,and able to carry on a conversation for a few hours,and be alive,afterwards of course she gets tired,and then later on in the day,i give her another one,and she is able to visit and hang out for a few hours.I think it has been such a life saver,because she hasn't slept her life away,she can actually interact with me,and her family for a short time.