Mother diagnosed with gallbladder cancer - help needed

On 9/9/2009 marzb6 wrote:

Hello

I just found this site and I'm so glad I did My mother was dx with GB cancer 1/09  stage IV we started tx that week the markers came down with the first tx ending in june 09 now we have been on 3 different tx and the markers keep going up and my mom is very emotionally drained thinking she's just sitting around waiting to die I need help as you know they gave her 6 mo to a yr I belive she is strong enough to go through more tx but it tears her down when they seem to not be working.. do you have any advise?

 

Marlene

Wow, Marlene, you ask a tough question. If we knew for sure that chemo would definitely help, then that would be one thing. Then it might be worth dealing with the side-effects and problems associated with chemo. But the chemo for GBC is an iffy thing, it appears, and results have been mixed. I assume there is no surgery and/or radiation option in your mother's situation. You did not mention the exact tx your mother has been on, I am assuming a mix of Gemzar (gemcitibine) and something like Oxiliplatin. Maybe Xeloda, 5 F-U. Anyway, some people tolerate these better than others. Your basic question go to the heart of the matter of quality of life. How much chemo vs. how much comfort? If you trust your mother's oncologist, or if you identify another staff member (nurse?) in that clinic who seems both knowledgeable and sympathetic, and who knows your mother's individual case, then i would arrange for a meeting and sit down and have an honest talk with them about these issues. Many larger cancer centers have staff hired to do just this type of thing. And I would do it soon, so that a new chemo regimen may be started.....or not. Oh and one more thing, you mentioned your mother being emotionally drained and "torn down" -- these are normal, totally. How can one not be? When I was diagnosed with gallbladder cancer, I certainly was that way. I asked my doctor for an antidepressant, and that has actually helped me quite a lot. Consider this for your mother, too. Please write again soon and let us know how things are coming along. I am wishing you the best outcome possible! Milly

Im sorry if this might be a bit mutch but it the only way I can explain it Ask her doctor but I think she would benifet from injections of vitamin D3 If  her CA19-9 is 2000 (CA = carbohydrate antigen) that a lot of  monoclonal antibodys she generated against  the carcinoma in her body.I feel  if she can ask her doctor about geting vitamin D3. it will desharm the cancer turmors  why I saying  this is she has so muich  monoclonal antibodys in her system the vitamin D3 will help deshurm her cancer so the chemo and the antybodys she produceing can kill it you see  cancer cells secrete an enzyme known as alpha-N-acetylgalactosaminidase (also called Nagalase) that completely blocks conversion of Gc protein to Gc-MAF, preventing tumor-cell killing by the macrophages. This is the way cancer cells escape detection and destruction, by disengaging the human immune system. This also leaves cancer patients prone to infections and many then succumb to pneumonia or other infections.

So I feel she will do well if she gos onto weekly injection of just 100 billionths of a gram of a harmless glyco-protein (a naturally-produced molecule with a sugar component and a protein component) activates the human immune system and cures cancer for good, according to human studies among breast cancer and colon cancer patients, producing complete remissions lasting 4 and 7 years respectively. This glyco-protein cure is totally without side effect but currently goes unused by cancer doctors.

Normal Gc protein (also called vitamin D binding protein), an abundant glyco-protein found in human blood serum, becomes the molecular switch to activate macrophages when it is converted to its active form, called Gc macrophage activating factor (Gc-MAF). Gc protein is normally activated by conversion to Gc-MAF with the help of the B and T cells (bone marrow-made and thymus gland-made white blood cells). But, as researchers explain it themselves, cancer cells secrete an enzyme known as alpha-N-acetylgalactosaminidase (also called Nagalase) that completely blocks conversion of Gc protein to Gc-MAF, preventing tumor-cell killing by the macrophages. This is the way cancer cells escape detection and destruction, by disengaging the human immune system. This also leaves cancer patients prone to infections and many then succumb to pneumonia or other infections

Normal Gc protein (also called vitamin D binding protein), an abundant glyco-protein found in human blood serum, becomes the molecular switch to activate macrophages when it is converted to its active form, called Gc macrophage activating factor (Gc-MAF). Gc protein is normally activated by conversion to Gc-MAF with the help of the B and T cells (bone marrow-made and thymus gland-made white blood cells). But, as researchers explain it themselves, cancer cells secrete an enzyme known as alpha-N-acetylgalactosaminidase (also called Nagalase) that completely blocks conversion of Gc protein to Gc-MAF, preventing tumor-cell killing by the macrophages. This is the way cancer cells escape detection and destruction, by disengaging the human immune system. This also leaves cancer patients prone to infections and many then succumb to pneumonia or other infections

http://www.lewrockwell.com/sardi/sardi84.html

to detect a monosialoganglioside found in patients with gastrointestinal adenocarcinoma. It is found it to be elevated in 21 to 42 percent of cases of gastric cancer, 20 to 40 percent of colon cancer, and 71 to 93 percent of pancreatic cancer, and has been proposed to differentiate benign from malignant pancreatic disease, but this capability remains to be established.