rash problem with Revlimid

Hello

My mom has luekemia and they are giving her Relimid since April 2009, the med. is working ok but when my mom takes it for more then 3 weeks she breaks out in a horrible rash and itching from head to toe and she has to stop take medication till it clears which can take another 3 weeks. Her doctor tells her to take Benadryl 4xs a day and he did prescribe an anti-itch cream but they really don't help.  Any suggestion would be appreciated.  Thank you concern daughter

I had a simliar issue when first placed on Thalidomide...basically the same drug as Revlimid (sister drugs).  It took a couple of months before the rash stopped returning.  When I switched over to Revlimid later in my treatment, due to other side-effects from the Thal, I didn't experience a rash sequence again.  I think your doc is on the right track.  However, if it doesn't go away soon, the doc might need to consider something else...or a lighter dose of Revlimid.  btw, I was on 10mg per day of Rev for 21 days with 7 days off before begining each 28-day cycle. 

Hope it all works out

I failed to mention, I have Myeloma so dosing might be different.