I have been on 50mg of Sutent, 4wks on 2 wks, off for 28 months. I get hand and foot syndrome from the Sutent. To reduce the pain of walking, I also take hydrocordone 10-325 (a mild opiate and tylenol pain reducer). Since I had one kidney removed, I wanted a low dose of tylenol in the hydrocordone. The hydrocordone usually causes constipation, however for me, the combination of Sutent + hydrocordone balances out during the time that I take Sutent. During the 2 wls off of both Sutent and hydrocordone, I have mild diarrhea for about one wk for which I take immodium a couple of times.
walking Jim