Pazopanib

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My wife had a radical nephrectomy in Jan., '05, lesions showed up 3 yrs later in lungs & liver, thought locally to be clear cell, 2d & 3d pathology opinions indicate chromophobe; she went on Sutent which worked for @ a year before progression, now in a clinical trial for investigative drug, Pazopanib, which caused SEs requiring dosage reduction by 1/2 but showed minor shrinkage on 1st CT, now on 4th cycle, continuous. I am interested in sharing info re Pazopanib w/ anyone else who has been or is now on it. Thanks!

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stgooch

Correction - she is now on the 3d 28 day cycle, continuous, of the Pazopanib, only the 1st was at the full clinical trial strength, the 2d & the one she is on now are at 1/2 strength, & she will undoubtable stay at that level as long as she is on it.

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RPB2009

Hi There,

just read your message and i've been keeping an eye on this drugs progress as it's not far off hitting the european market.

i was wondering where abouts in the world this trial is taking place (US/UK) as i'm in the UK, have failed Sutent after 14mths, i'm currently on Everolimus which seems like it's not working & am looking for the next possible treatment.

can i also ask roughly what percentage tumour reduction you experienced & whether this continued over the following cycles or did the tumours then stabalize?

Many thanks

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3 Posts | Page(s): 1