My DH's liver numbers (normal range being - I think - 4 to 60 or something like that) had skyrocketed to 1800 (yes, FOUR DIGITS) while he was on decadron. When we lowered the decadron, the numbers came down; when we'd have to increase the decadron, the numbers would go back up again).
I know in some situations the decadron is a must-have, but gratefully, Tom was eventually able to wean off it completely and now has been decadron free for several months, with no increase in brain tissue swelling.
When it's possible to decrease or remove the decadron altogether, maybe that'll help.
In the meantime, Tom didn't have to take any additional drugs or anything to control those numbers: he stayed away from alcohol and tylenol; I don't think he took any other specific actions to mitigate those high, high numbers.
Hope this helps -- Take care - Linda