We are in a hard place right now with treatment and seizures. Rick (my husband) had a recurrence (in Feb) after 9 months on Temodar (AAIII) In March he went on Avastin and CPT 11 and the spots went away. His NO stopped the CPT 11 and kept the Avastin. After 2 months of that the spots came back, plus his T2 and Flair signal (in another location representing low grade tumor, his NO says) increased significantly. He went back on CPT 11 and the spots went away. The flair has remained high so we have added Carboplatin to the mix. He gets CPT 11 and Avastin, two weeks later, Carbo, CPT 11 and Avastin. This is our second month (he just had the carbo, CPT 11 and Avastin for the second time yesterday). His seizures have steadily increased over the past 2 1/2 months. His last 3 MRI's (done every month) have been stable, but his seizures are not getting any better. He is at the amximun dose of Keppra (3500 mgs.) and also taking Vimpat twice daily at 200 mgs. His NO has started him on .25 of Klonipin in the AM and .50 in the evening. Has anyone else had trouble with seizures like this? I have been told that chemo can lower the seizure threshold, along with sickness, stress etc. Any suggestions as to how to get them under control. He is having another MRI on the 15th and I am praying for good news...but his partial seizures are a great concern right now. He will go for a day or two and then have one. He seems to be having them about every other day. No real rhyme or reason for them that I can come up with. Help!
Thanks for any input you may have.
Debbie