hi christine my twin a has stage 4 cancer and yes after 6 months of chemo they did a scan and the chemo was not hgolding the spots at bay they were growing a little on her lungs and liver so now they started her on another mixture of chemo drugs.Inwas told that when yhe chemo stops doing it,s job they try the next one until they have no more.I,m sorry that is not what you would not want to hear but it is likely what will happen .My twin is also doing grat at this time so lets allhope they find something out there that will stop this all together.