For some it is prescribed for use on the lips. I used it on my face and lower lip per doctor's orders. My lip reacted and blistered and peeled and looks better than before but it was uncomfortable for about a week. So if you were not told to use it there than don't of course, but you don't need to worry abou a small amount getting there. IF you have AK's on your lips they will react ot it, if you dont than your lips wont respond anyway. Hope that makes sense.