Hi Mazuri,
To answer both of your notes.
I have known the crust to crack and then to bleed. I think it says don't treat open wounds but I allowed it to recrust and then carried on as it was only small. They use fluororicil as an internal chemo so I thought to carry on unless I get a side effect. My doctor didn't comment on this but in general he's very flexible with Efudix. He says some patients use it long term twice a week and others just at weekend. If you're doing a proper course though I'd stick to the daily dose.
I'd also suggest that if it's crusting it's almost done and you could let it heal and then repeat the course in that area.
I've treated my scalp 3 times in 15 months with one area in particular being done for 6 weeks in one course, although my doctor didn't know. In my opinion it's better now than it's been for 15 years (I'm 60) and gets better each time.
On the other hand my doctor says that for persistent or hard AK he'd rather curette it out, I had 9 curetted 2 yrs ago. He says removing skin is the only sure way.
I've also read on here of other people being told to do second courses.
I'm seeing the doctor later today on my 6 monthly inspection and have 4 small AK in one area just above my forehead. Shame really as it's really smooth everywhere else.
Overall I'm optimistic that Efudix is doing the job and don't mind using it in small areas twice a day for 14 days. Although that's against my doctors orders of once a day.
Just hang on in and keep at it. Good luck.