Women who don't have BRCA mutations could have other high-risk genes that affect treatment choices
by Corazonlatina59 on Thu Nov 12, 2009 01:20 AM
My dad was just diagnosed last Friday with Stage 4 Lung Cancer. Today he had his first visit with the oncologist and she is wanting to do a brain scan to make sure the cancer has not progressed to it before starting his chemo... Just how often do Stage 4 patients find that the cancer has gotten to the brain?
by kz7m on Thu Nov 12, 2009 05:48 AM
CALGARY, Nov. 6 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:ONC, NASDAQ:ONCY) ("Oncolytics" or the "Company") today announced updated results from a Phase II study of intravenous REOLYSIN® in patients with sarcomas metastatic to the lung in a poster presentation at the 15th Annual Connective Tissue Oncology Society Meeting held in Miami Beach, Florida, from November 5th to 7th. The poster presentation, entitled "A Phase II Study of Intravenous REOLYSIN (Wild-type Reovirus) in the Treatment of Patients with Bone and Soft Tissue Sarcomas Metastatic to the Lung", was delivered by Dr. Kamalesh Sankhala, part of principal investigator Dr. Monica Mita's team at the Institute of Drug Development (IDD), the Cancer Therapy and Research Center at the University of Texas Health Science Center, (UTHSC), San Antonio, Texas.
The investigators reported that the treatment has been well tolerated to date, and that 19 of 44 evaluable patients experienced stable disease ranging from two to 20 months, resulting in a total clinical benefit rate (complete response + partial response + stable disease) of 43%. The response objective for the study was three or more patients having prolonged stabilization of disease (greater than 6 months) or better, for the agent to be considered. The trial exceeded its established objective with six patients experiencing stable disease for more than six months. Two patients have experienced stable disease for more than 19 months. One has synovial cell sarcoma that relapsed following surgery, while the other has Ewing's Sarcoma and had previously progressed following multiple treatments.
"We were very happy to participate in the study," said Dr. Mita. "REOLYSIN is a promising option for patients with sarcoma as shown by the results of this study. As a single agent the virus had a clinical benefit rate of 43% and it was very well tolerated. Further studies combining REOLYSIN with chemotherapy are contemplated in order to integrate the virus in the panoply of agents used for sarcoma treatment."
"These results are consistent with what we observed on an interim basis when we reported data on the first 16 patients back in June 2008," said Dr. Brad Thompson, President and CEO of Oncolytics. "It is encouraging that we are observing stable disease in a range of sarcomas and the clinical benefit is not isolated to any specific type."
A copy of the poster will be available on the Oncolytics website today.
by kz7m on Thu Nov 12, 2009 05:50 AM
by kz7m on Thu Nov 12, 2009 06:19 AM
by heavenhelpus on Thu Nov 12, 2009 05:42 PM
I'm very sorry to hear about your dad. My brother-in-law had stage 4 lung cancer with mets to the brain, never went anywhere else, sad to say he passed away 2 years and one month after the diagnosis. My husband was diagnosed almost 2 years ago with stage 4 lung cancer also. His mets are to the brain, arm, hip, femur, chest, breast, just recently kidney and a few tumors just popped up on his back, one is very close to his spine. He amazingly is much more mobile (even with all these mets!), then my brother in law was. I think that has to do with where in the brain the tumors are located.
So, to answer your question, yes lung cancer has a high chance of moving up to the brain.
I hope that surgery will be an option for your father.
God bless you and your family.
by behappytoday on Sat Nov 14, 2009 04:32 AM
I am a four year survivor of stage four lung cancer. I have had PET scans and CT scans however I have not had a brain scan. The only thing that I can suggest is to get a second opion on just about everything. When I first found out that I had lung cancer one doctor told me somthing that I will never forget, he said "if anyone tells you a absolute, get a second opion".
If I can help, contact me at: firstname.lastname@example.org
by hayesammk on Thu Feb 04, 2010 06:34 AM
On Nov 12, 2009 1:20 AM Corazonlatina59 wrote: My dad was just diagnosed last Friday with Stage 4 Lung Cancer. Today he had his first visit with the oncologist and she is wanting to do a brain scan to make sure the cancer has not progressed to it before starting his chemo... Just how often do Stage 4 patients find that the cancer has gotten to the brain?
On Nov 12, 2009 1:20 AM Corazonlatina59 wrote:
My mom got lung cancer in 2004 and it was first in the lung, that got removed. After removed about a year later she got the brain tumor. Luckily was also removable. She has had 4 chemo's since then and other things, but currently getting a scan to see if her adrenal gland cancer has spread. We are hoping of course that it has not spread. Keep up the positive thoughts and prayers and take one day at a time.
by Chessie on Thu Feb 04, 2010 12:28 PM
There is really no way to tell if a patient will develop brain mets. A brain scan is usually done as part of the evaluation because when lung cancer spreads, the brain is one of the first places it spreads to. But that doesn't mean it already has.
I was diagnosed stage 4 with multiple tumors in both lungs. My brain scans have all been clear. And I was diagnosed in October 2006. Am currently in remission.
Just as info, the targeted drug Tarceva crosses the blood/brain barrier and helps prevent brain tumors. Most of the IV chemos do not cross this barrier. I started out on tarceva 3 years ago and am still taking it; however, I have never had any mets anywhere and all original tumors are gone. Just something to keep in mind when they set up his treatment program if he decides to have treatment.
Every case is different, but as you can see, there is hope. And miracles do happen every day.
Good luck and God Bless
by creekgirl_sc on Tue Feb 16, 2010 11:06 PM
I had my cancer start in my lungs & had the URL removed in Nov.07. Staged at 111A. They then told me no cancer to be seen...ha.
On one of the routine chest CT scans they did to check for any new tumors (after about 9 months) they saw more little tumors. Then restaged to IV. They wanted to start me on Avastin & Tarceva but wouldn't start until they checked for any brain tumors. And they found two.
I had the cyberknife done in Jan. 09 & they both disappeared. Since then an MRI every 3 months & last week they saw another one had started. Nothing to be done except to watch for any growth.
My onc. told me that lung cancer "loves to go to the brain if it's going to go anywhere". It is one of it's favorite places to go. I don't know why that is but it happened.
Hoping all goes well for your Dad. It's scary when you first hear the words & you feel so helpless. But after a plan of action is put in place I think he will feel that he has more control. And prayers never hurt either.
by vel10 on Mon Apr 12, 2010 09:45 PM
My mother was DX with stage four small cell lung cancer about 3 wks ago.
I think it is fairly common that the brain is one of the first places it goes, especially if in the lymph nodes.
They have been trying very hard with out success to get a scan of my mothers brain but she had a intense fear of small places. So she has not gotten one.
She has completed one round of chemo just about a week and a half ago and has already landed in the hospital with an infection and zero white blood cells.
The dr. ordered a blood transfusion and also said he doesnt see the 3 tumors she had as being there anymore. Like it disappeared.
I wonder if this happens to many people. I do believe in miracles, but still want to know if anyone else has experianced any of this??
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