Pazopanib

Is anyone familiar with this medication? My mother will begin a clinical trial with it and I was wondering if anyone has had experience with it before? What have been the results and also the side effects? Thank you for any information you have.

Pazopanib is one of the new VEGF inhibitors. Although Glaxo has announced beginning of Phase III trials of Pazopanib, I have not been able to find published results of Phase II trials. Your mother's doctor may have this information. Most commonly reported side effects were high bookd pressure and fatigue.

There is an email support list for kideny cancer. See http://cancerguide.org/kofaq/ to join.

This drug could end up being a blockbuster.

And on Pazopanib, early clinical data showed that the compound has strong anti-cancer activity. A first-round trial showed that all 63 patients with renal cell carcinoma, a form of kidney cancer, experienced tumor reduction or disease stabilization. Similar results were found in other cancer types, including gastrointestinal, lung, and thyroid cancer, said the company.

The company did not disclose when it will file for FDA approval for the drug

This drug could end up being a blockbuster. I would take my chances with this one. Has Interleuken 2 been tried yet. It has a 1 in 5 chance in working, and when it does work it really works. As with Pazopannib, It is already having better results then Nexavar. Also, there is a lot of people out there that think that diet has nothing to the do with cancer. Research the budwig diet. Diet can make a real difference.

Hi

Can you show me where to find the information/report(s) on these results - i.e. 63 RCC patients ? I could only find reports of 3 RCC patients responding.... Thanks!!

If anyone is still looking for the published results of phase II trials, they were published in the journal Clinical Genitourinary Cancer in March 2006, volume 4, number 4, pp. 296-8. You can purchase the three-page article for $20 at this address:
http://www.electronicipc.com/journalEZ/detail.cfm?code=39560

I beg your pardon; I had our secretary order the article mentioned above, and it does not present any results of these studies. It's just a profile of the design, rationale and anticipated results. I don't recommend it as this information is available for free elsewhere on the internet.