From Mtaj57; stage 4 and 8 full months on sorafenib, I am still doing well, if I keep after my feet,by removing any hard skin or blisters,hands are not as good as they once were,less feeling and dry.Am on a doseage of 400mg a day and sometimes i'll try 800,but the diarrhea gets to me within a couple of days,which leaves me feeling washed out and tired,so 2 pills is pretty much it for me,last cat showed a small amount of growth in the smallest tumor in my RT lung,the left lung is stable at zero growth,and nothing new is being found anywhere else,if there is any changes towards new growth,I will be shifting over to Sutent,which my doctor thinks may work better.I measure my life into fishing trips to Alaska and hunting in my home state of Nevada,in other words, stay alive and well for the next trip...Seems to work