Women who don't have BRCA mutations could have other high-risk genes that affect treatment choices
by Oncrx on Wed Aug 04, 2010 12:17 PM
new from ASCO, FOLFIRINOX (with full-dose oxaliplatin and irinotecan) not only improved progression-free survival and response rate but also overall survival (from 6.8 to 11.1 months) when compared to Gemzar in patients with metastatic pancreatic cancer. Some more side effects but this could be a great option for younger, healthy patients.
by bytm722 on Sat Nov 13, 2010 04:37 AM
My FIL just completed his 1st round of this today. We are scheduled for round 2 Mon. after Thanksgiving. <--- =)
Has anyone else been given this treatment plan? What was your experience with it?
by daves on Thu Nov 18, 2010 03:23 AM
I just completed 6 rounds. I was given in Thurs to Saturday (3 days) and repeated every two weeks. For me, the major side effect was diarrhea. I am 50 and the intent was to shrink my tumor enough to have surgery. They did a PET and CAT Scan after four rounds, and found the tumor was almost not detectable. My oncologist and surgeon couldn't believe the results. They are now seeing from other results they've never seen before regarding shrinking of the tumor. I go back tomorrow for a PET scan to see if the additional two rounds had any benefit. I am scheduled for the Whipple in December at Sloan Kettering.
by blackberry on Fri Nov 26, 2010 05:39 AM
Daves, any updates?
by melibob on Fri Nov 26, 2010 04:02 PM
Hello, all. As we are all touched somehow by this horrendous disease, it is my prayer at this time of Thanksgiving that we all are able to find many things for which to be thankful. The Bible tells us to "Be thankful in all things." Wow..sometimes that is a hugely difficult thing to do .... but I trust each of us is able to do so.
My question.... my almost 72 year old sweet husband is currently on a Folfox regimen... every 2 weeks he has a 3 hour IV drip at the hospital and then a 46 hour drip into his port with a fanny pack pump at home. What is the difference in Folfox and Folfirinox? Does anyone know?
I am assuming it is the Irinotecan. Since this was a message from 2004, has this been found to be less effective than Folfox?
Blessings to all.... Meli in Texas
by cercata on Tue Nov 30, 2010 05:26 PM
I hope this round went well.
I am trying to find out where everyone getting Folfirinox is getting it- at what medical centers? Where is your FIL being treated? I'm trying to find this regimen for a newly diagnosed, not yet treated friend.
This combination looks promising. Could others on this tell me where you are getting it?
by melibob on Tue Nov 30, 2010 08:15 PM
Bob, 72, is getting his Folfox at M D Anderson Cancer Center in Houston. His pancreatic cancer has metastasized to the liver. He had been on Tarceva, after 6 months on Gemcitibine and Cisplatin, as well as radiation and Xeloda...nothing has fazed him nor his tumor. I asked about Folfirinox yesterday during his treatment. The oncologist said that the side effects from the Folfirinox are mighty tough...yes, the research is showing promise, but M D Anderson is tending to using it more on younger, healthier patients. My Bob's age, heart disease, diabetes as well as the cancer indicates to them that he wouldn't be a good candidate for Folfirinox at this time. Meli
by blackberry on Tue Nov 30, 2010 10:05 PM
I think you should be able to get it pretty much anywhere. With stage IV they pretty much give you three options with Chemo. I believe the FDA approved of this regime back in July so you might have some trouble with having your insurance approve it at first.
by squand on Tue Nov 30, 2010 11:48 PM
I will start with this group of drugs next wed...
by cercata on Wed Dec 01, 2010 02:15 AM
Meli, thank you so much for your reply. Boy, sounds like he's been through a lot. I 've read that the Folfirinix s/e can be really difficult. I've seen that it is recommended for younger people. I hope the Folfox works well for your Bob.
Rick, good luck with your treatment; I hope it goes well. Where are you getting this?
Blackberry, thanks for your response. This isn't FDA approved, although all the meds that constitute this regimen are. We've been looking at trials, and combinations that different centers are trying.
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