Women who don't have BRCA mutations could have other high-risk genes that affect treatment choices
by cancerbeater on Mon Jan 03, 2011 06:46 AM
I have mets to lungs and now to liver after nephrectomy in '06. Has anybody been on Sutent first and then after failing other treatment (like HD IL-2, Votrient, Afinitor) gone back to Sutent again? My Onc suggested going back to Sutent as another option after failing Afinitor, but I don't see the point. Any input on this matter will be appreciated.
by Maria1981 on Tue Jan 04, 2011 01:09 PM
I was thinking about this option. I was wondering if a drug stopped working because of the long-term usage, may be after a break it will work again? Some drugs do, may be here it is also the case.
I don't know if anyone has tried this way, though.
by cricket67 on Wed Jan 05, 2011 07:08 PM
Here is an interesting article I read several months back regarding Sutent resistance.
Van Andel Research Institute (VARI) researchers have found a way to reverse resistance to sunitinib.
ChrisDiagnosed July 29th, 2008 RCCStage IV, with spread to both lungs and lymph nodes.Full left nephrectomyTreatments:IL2 – Did not workCurrent - Phase II Sutent and AMG 386 - On 15th cycleLast scan results revealed no metastatic disease found.
by cancerbeater on Thu Jan 06, 2011 04:33 AM
Thank for you info, Chris. Will check it out. Definitely something to look forward to. Glad to hear you are doing well with the trial. Keep it up. Just curious what kind of side effects you are having, if any? Thanks & Take care.
by cricket67 on Thu Jan 06, 2011 01:43 PM
I have all the normal side affects of Sutent. Upset stomach, hand/foot issues and taste bud loss. The feet and hands have lessened over time. I make sure I lube them up everyday, even on my two week break.
by reggofish on Thu Jan 06, 2011 10:55 PM
Chris Glad to hear of your progess. I have been on Sutent for 18 months and most side effects have gotten less severe but one has gotten worse. Have you had any problems with your butt? I am having a lot of pain and some bleeding. I am looking for anything that might help.
by JEFF_A on Fri Jan 07, 2011 12:40 AM
Just to let you know.
When i went on sutent (june 2010 50mg) i been on for 14 days and off 7 all the time.
My ong says the side effects are not as bad and the results have been the same on studys.
by JEFF_A on Sat Jan 08, 2011 02:41 AM
Hope u r feeling well.
Just keep the butt as clean as u can. I use baby wipes and then wipe with soft toilet paper.
Also i use baby powder after.
Hope this helps you
by LeighAllen on Sun Jan 09, 2011 10:29 PM
My husband was also dx'd in 2006. He had mets to both lungs at the time. His tumor was 10 pounds, resected from liver and vena cava. He did HD-IL2, Sutent, Nexavar, Afinitor, Sutent, Votrient. Sutent is the only med that has worked for him. He was on it the first time for 18 months and ten went to Nexavar and Afinitor. Neither worked. We re-challenged Sutent and it worked again ~ this time only 12 months but still, it worked! My husband is currently on Gemzar and Xeloda. If the scans show they aren't working, I may ask his onc to put him back on Sutent as he is running out of options.
Definitely rechallenge a med that has worked in the past. It can work if it's worked previously.
Blessings ~ Leigh
by cancerbeater on Mon Jan 10, 2011 02:45 AM
Thank you LeighAllen. I was kind of skeptical when my onc mentioned Sutent as my other option, but after hearing about your husband's experience, I find hope again. What dosage of Sutent did your husband take when he went back on it? My last 5 cycles were of 12.5mg (28days with 3wks off) due to low WBC. Also curious why your husband didn't try Avastin(by itself)? That likely would be my next option if Afinitor(5mg) doesn't work for me. Hope Gemzar & Xeloda will keep your husband well. Thank you for responding.
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