Kidney Disease - Side Effect of Cysplatin Chemo

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Kidney Disease - Side Effect of Cysplatin Chemo

by foxwoodsqueen777 on Tue Feb 15, 2011 07:13 PM

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My husband was treated for Stage 4 Tonsil in 2009.  He has been cancer free to date.  However,  he has developed moderate to severe kidney disease as a result of his chemo sessions.  His GFR (Glomerular Filtration Rate) is 39.  Kidney failure GFR is less than 15.  I've done research and found out that 1 of 3 cancer patients who were treated using cysplatin developed some form of kidney disease.   The outlook does not appear to be good as the disease never goes away; you can slow down its progression with life style changes.  Am wondering if anyone else developed kidney disease as a side effect of their cysplatin chemo therapy.  Nephrologist could not say if he will be on dialysis in one month or five years.   He is 59 years old.  Normal GFR is estimated at 93.  He is not a diabetic, does not have high blood pressure, does not smoke, exercises and is slendor.  There isn't much we really can do to slow down its progression.  Would like more information.  Thanks - Phyl

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by Jeannielu on Wed Feb 16, 2011 04:38 AM

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I cannot answer you questions, but thankyou for posting this. My husband has Stage 4 neck cancer also, he just had the surgery done and will be starting radiation and chemo very soon. He has Polycystic Kidney disease that was diagnosed 1 year ago and his GFR is also at 39 right now. I have been so worried what the chemo would do to his kidneys. We will see his oncologist this week and I will ask him about this treatment before we agree to chemo.  As for the kidneys the best thing he can do is follow a low sodium diet and stay away from sodas. Also limit any high sugar products as they really affect the function. Look up kidney diets to follow, it does help but will not of course cure it. We try really hard to do anything that will slow the process down as the only  thing they can do will be dialisys or transplant. Thankyou for your story and I will try to get us some answers for this problem/

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by Roselvr on Wed Feb 16, 2011 03:57 PM

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On Feb 15, 2011 7:13 PM foxwoodsqueen777 wrote:

My husband was treated for Stage 4 Tonsil in 2009.  He has been cancer free to date.  However,  he has developed moderate to severe kidney disease as a result of his chemo sessions.  His GFR (Glomerular Filtration Rate) is 39.  Kidney failure GFR is less than 15.  I've done research and found out that 1 of 3 cancer patients who were treated using cysplatin developed some form of kidney disease.   The outlook does not appear to be good as the disease never goes away; you can slow down its progression with life style changes.  Am wondering if anyone else developed kidney disease as a side effect of their cysplatin chemo therapy.  Nephrologist could not say if he will be on dialysis in one month or five years.   He is 59 years old.  Normal GFR is estimated at 93.  He is not a diabetic, does not have high blood pressure, does not smoke, exercises and is slendor.  There isn't much we really can do to slow down its progression.  Would like more information.  Thanks - Phyl

Thanks for posting- can you tell us what symptoms your hub was having?

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by copelandjr on Fri Feb 18, 2011 02:43 AM

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I had renal cell carcinoma,(1983) lost left kidney and had CKD in the remaining kidney(1989).I lived on one kidney for 10 years when I received a "so far" successful kidney transplant (1999).  

Creatinine(function level), BUN(Toxic) and GFR is blood work has certain levels before losing kidney. My creatinine was 7.2(today.09), BUN was 97, today(14), and GFC was 9, today 72. GFR SOMETIMES CAN BE LOW BECAUSE OF POSTRATE PROBLEMS OR CERTAIN MEDS ESPECIALLY PAIN PILLS, also African American has different reads than whites.

Drink lots  water, no red meat, I have ate  Mediterrean Diet since my transplant and find this has help my longivity. A glass of red wine with meals is beneficial.

I have battle Large B Cell Lymphoma for 9 years having 150 plus radiation treatments and room full of chemo`s yet my kidney ahd survived. I am 73 years old and had my transplant at 62.

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by tammyo on Fri Feb 18, 2011 04:23 PM

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Hi Copelandjr,

I am a stage 4 RCC patient. They took out my kidney, spleen and half my pancreas.  I was on Sutent for 4 years and it damaged my remaining kidney to a point where they said I would have to be on dialysis, so they changed my meds even though it was working on the tumours. When I asked if I could get a transplant (I had 3 people ready to give me their kidney), they said it was not an option at all, so how come you got a transplant?  If you have any idea as to what your doctors said, I would be grateful to hear it.

thanks

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by foxwoodsqueen777 on Fri Feb 18, 2011 10:50 PM

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On Feb 16, 2011 3:57 PM Roselvr wrote:

On Feb 15, 2011 7:13 PM foxwoodsqueen777 wrote:

My husband was treated for Stage 4 Tonsil in 2009.  He has been cancer free to date.  However,  he has developed moderate to severe kidney disease as a result of his chemo sessions.  His GFR (Glomerular Filtration Rate) is 39.  Kidney failure GFR is less than 15.  I've done research and found out that 1 of 3 cancer patients who were treated using cysplatin developed some form of kidney disease.   The outlook does not appear to be good as the disease never goes away; you can slow down its progression with life style changes.  Am wondering if anyone else developed kidney disease as a side effect of their cysplatin chemo therapy.  Nephrologist could not say if he will be on dialysis in one month or five years.   He is 59 years old.  Normal GFR is estimated at 93.  He is not a diabetic, does not have high blood pressure, does not smoke, exercises and is slendor.  There isn't much we really can do to slow down its progression.  Would like more information.  Thanks - Phyl

Thanks for posting- can you tell us what symptoms your hub was having?

Kidney disease is silent.  He really had no symptoms; urine flow etc. was normal.  I understand that the nerve damage in his feet is a symptom of kidney disease which cysplatin causes.  We found out about his situation when he went for blood work that certain levels were out of range and during the last three months, the levels are worse.  That is why his oncologist turned him over to a nephologist (spellilng???) - kidney specialist.

RE: Kidney Disease - Side Effect of Cysplatin Chemo

by Roselvr on Fri Feb 18, 2011 11:13 PM

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On Feb 15, 2011 7:13 PM foxwoodsqueen777 wrote:

My husband was treated for Stage 4 Tonsil in 2009.  He has been cancer free to date.  However,  he has developed moderate to severe kidney disease as a result of his chemo sessions.  His GFR (Glomerular Filtration Rate) is 39.  Kidney failure GFR is less than 15.  I've done research and found out that 1 of 3 cancer patients who were treated using cysplatin developed some form of kidney disease.   The outlook does not appear to be good as the disease never goes away; you can slow down its progression with life style changes.  Am wondering if anyone else developed kidney disease as a side effect of their cysplatin chemo therapy.  Nephrologist could not say if he will be on dialysis in one month or five years.   He is 59 years old.  Normal GFR is estimated at 93.  He is not a diabetic, does not have high blood pressure, does not smoke, exercises and is slendor.  There isn't much we really can do to slow down its progression.  Would like more information.  Thanks - Phyl

Thanks. Just looked it up- links below.

Kidney disease symptoms - http://kidney-disease-symptoms.com/

Mayo- http://www.mayoclinic.com/health/kidney-failure/DS00682/DSEC

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