Folfiri With Avastin

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Folfiri With Avastin

by Meghan26 on Wed Jun 28, 2006 12:00 AM

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My husband was taking Folfox4 without Avastin and will now be taking Folfiri with Avastin. Has anyone done Folfiri with Avastin and if so, any experiences with bad side effects? Any info is helpful. My husband is only 31 and has been diagnosed with stage 4 rectal cancer. Anyone else with similiar situation, I would be glad to communicate with. Thanks!!

Avastin

by Lynn_S_5 on Thu Jun 29, 2006 12:00 AM

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I, too, was diagnosed with stage 4 colorectal cancer in Nov. 2004. I had only 2 treatments of avastin along with the standard chemo, and had no side effects any different than without Avastin. I only had 2 treatments and the metastasized tumor on my liver was completely dead. I had 1/2 of my liver removed, and have been cancer free so far. I pray that your husband will also have a postive response to his treatments. Take care and stay positive.

Wonderful

by Meghan26 on Fri Jun 30, 2006 12:00 AM

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Thank you for responding. That is wonderful that you are cancer free!! Positive news is nice to read. God Bless you and I hope you remain healthy.

Stage 4 Here Too

by Debbied30 on Tue Aug 08, 2006 12:00 AM

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Hi , My husband is also young , he just turned 35 years old and was originally diagnosed with stage 4 colon cancer in Sept 04, he did folfox with avastin, and surgery ( surgery first) last treatment was june 6 2005. Unfortunately he is starting chemo again tomrrow for a reoccurence , this time its throughout his abdomen and surgery is not an option. Doc says chemo will not be for a cure only to extend life. Horrid road we have to travel. He will be starting folfiri with avastin tomorrow. Has your husband started treatments yet? Deb

RE: Stage 4 Here Too

by rene48 on Thu Feb 28, 2008 12:00 AM

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my girlfriend has stage 4 appendix cancer with signet ring cell and for her to she is on folfiri with avastin to prolong. she has abdomen pain and loss of balance and cold sensitive. she also is always tired about the third day after chimo. but she cannaot sleep on the first day of chimo and she talks all night non stop. other than that well it is a very difficult journey.

i wish you all the luck in the world and keep hoping

RE: Folfiri With Avastin

by Robert7777 on Mon Jan 26, 2009 12:00 AM

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Hi, in response to your message regarding FOLFIRI w/Avastin that is what was recommended to me post chemotherapy with FOLFOX w/Avastin.  I had colon cancer located in the transverse colon with stage 4 mets to the liver...i.e. two visible leisons.  The colon tumor was removed and in November 2008 all my scans were negative, However my 90 follow up revealed and elevated CEA of 17.4 which resulted in an immediate colonoscopy which came back negative then a CT the next day which provided definitive images of two leisons in the right lobe of the liver.  I have an appointment with a liver surgeon on Tuesday as well as a PET scan to see if the cancer is metastatic to any other area of the body.  The next course of chemotherapy will be the FOLFRI w/Avastin if the liver is not resectable.  My prayers are there for all of you and your families, it is a difficult road as you are all aware.

Robert T

RE: Folfiri With Avastin

by jules10100 on Mon Feb 09, 2009 12:00 AM

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HI Robert, I have stage IV Rectal cancer, I had a colon resection in June 2007, then radiation and chemo. Finished chemo in April 08, then had scans in Oct 08 at which time they discovered that it had metastasized to my liver and lung. I had a liver and lung resection on the 23rd of January and will be starting chemo again once my incisions have healed. I am 47 and hopefully strong enough to beat this thing. Good luck to you!

RE: Folfiri With Avastin

by Robert7777 on Tue Feb 10, 2009 12:00 AM

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On 2/9/2009 jules10100 wrote:

HI Robert, I have stage IV Rectal cancer, I had a colon resection in June 2007, then radiation and chemo. Finished chemo in April 08, then had scans in Oct 08 at which time they discovered that it had metastasized to my liver and lung. I had a liver and lung resection on the 23rd of January and will be starting chemo again once my incisions have healed. I am 47 and hopefully strong enough to beat this thing. Good luck to you!

Thanks for the encourgement, I started with colon cancer as you did in March of 2008, had the resection at which time they found a leison in my liver however Kasier did not have the depth in surgical physicians at the same hospital to remove the leison at the sametime. I had a 6 month course of Folfox5 w/Avastin and one other chemotherapy drug which escapes me now.  In November my CT, PET and MRI scans were clear. January of 2009 my CEA jumped to 17.4 which was not good.  After a colonsocopy which came back negative and CT was done and the leisons had come back in my liver.  A liver resection was scheduled however a PET scan revealed 5 leisons not 2 original ones observed in the CT.  One leison was on the other side of the liver which was not going to be involved in the resection so my surgeon said while technically he could remove all 5 leisons I would only be left with 25% of my liver which could fail due to my size and not having enough of the organ to sustain my body. He further told me that other leisons could be present which are not being picked up by the current scans and if they appeared after the surgery I would not be able to go back into chemotherapy immediately due the time required for the liver to heal and regenerate.  I have elected to go back on chemotherapy however apparently one of the components of Folfiri is not available at this time so the cocktail was replaced with XELIRI/Avastin/Irinoticen then 2 weeks of Xeloda, 4 500mg in moring then 12 hours later another 4 500mg tablets.  Lots of fun to be sure, while the prognosis is not wonderful I am keeping a positive attitude and looking for any information which is helpful.  Good luck with your treatments my prayers are with you.

Robert Thomas

RE: Avastin

by Robert7777 on Tue Feb 10, 2009 12:00 AM

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On 6/29/2006 Lynn S. wrote:

I, too, was diagnosed with stage 4 colorectal cancer in Nov. 2004. I had only 2 treatments of avastin along with the standard chemo, and had no side effects any different than without Avastin. I only had 2 treatments and the metastasized tumor on my liver was completely dead. I had 1/2 of my liver removed, and have been cancer free so far. I pray that your husband will also have a postive response to his treatments. Take care and stay positive.

 

RE: Avastin

by Robert7777 on Tue Feb 10, 2009 12:00 AM

Quote | Reply
Thanks for the encourgement, I started with colon cancer as you did in March of 2008, had the resection at which time they found a leison in my liver however Kasier did not have the depth in surgical physicians at the same hospital to remove the leison at the sametime. I had a 6 month course of Folfox5 w/Avastin and one other chemotherapy drug which escapes me now. In November my CT, PET and MRI scans were clear. January of 2009 my CEA jumped to 17.4 which was not good. After a colonsocopy which came back negative and CT was done and the leisons had come back in my liver. A liver resection was scheduled however a PET scan revealed 5 leisons not 2 original ones observed in the CT. One leison was on the other side of the liver which was not going to be involved in the resection so my surgeon said while technically he could remove all 5 leisons I would only be left with 25% of my liver which could fail due to my size and not having enough of the organ to sustain my body. He further told me that other leisons could be present which are not being picked up by the current scans and if they appeared after the surgery I would not be able to go back into chemotherapy immediately due the time required for the liver to heal and regenerate. I have elected to go back on chemotherapy however apparently one of the components of Folfiri is not available at this time so the cocktail was replaced with XELIRI/Avastin/Irinoticen then 2 weeks of Xeloda, 4 500mg in moring then 12 hours later another 4 500mg tablets. Lots of fun to be sure, while the prognosis is not wonderful I am keeping a positive attitude and looking for any information which is helpful. Good luck with your treatments my prayers are with you.
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