Women who don't have BRCA mutations could have other high-risk genes that affect treatment choices
by ChemoLite on Fri Jul 15, 2011 08:48 PM
After receiving Folfox, I developed severe toxicity 3 days after the infusion pump was removed and continued for 5 days-semiconscious. A reduced dose of the oral drug, Xeloda, was used for a second round. One week into the two weeks severe toxicity again appeared. Fortunately, this time I could discontine the pill--This may have saved my life.
Today a month later, I saw my Oncologist. Her recommendation:
"Unfortunately, given your very difficult time w/ The 5FU based chemotherapy, I do not have any good alternative w/ which to treat you wherein there is data regarding improvement in overall survival. Given this, I do not recommend any further chemotherapy at this time."
I've read that others have had problems metabolizing this drug and they have used another drug successfully, but am lacking specific information on which drugs and/or any testing administered to possibly warn of toxicity. Any help would be greatly appreciated.
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