Scientists suspect low-dose effects have led to global epidemic
by Lloyd on Mon Oct 10, 2011 04:18 PM
I've been dealing with RCC stage IV since 2001. Gone through IL2 and now, on sutent since 2008, but it is no longer effective. I'm entering a clinical trial using MDX 1106, It's a phase 2 trial to determine dosage amounts. Anyone been through the phase 1 trial or have any information ?
by SusanJS on Fri Oct 14, 2011 04:53 AM
I am interested in the reply to this. My husband may also participate in this trial. Sutent has stopped working for him (started July 2010). The alternative/next drug selected would be everolimus (Afinitor). Any information on BMS936558 (MDX1106) would be helpful.
by solovemymom on Thu Nov 10, 2011 08:14 PM
How are you doing on the trial ? My Mom has been on the trial for 12 weeks and her 2 CT scans so far show significant shrinkage to her tumors and she has almost no side effects other than being a little tired once in a while ! I pray you are doing well also ! I posted about this trial on 11-02-11 and referred to it as Phase ll Trial for BMS-936558. My Mom had has been on Sutent, Nexavar and Votrient. Please let me know how you are doing.
God Bless You,
by solovemymom on Thu Nov 10, 2011 08:24 PM
I just replied to Llyod also. My Mom has been on this trial for 12 weeks and is having a Fantastic response with signifcant shrinkage of her tumors and almost no side effects ! My Mom was previously on Sutent, Nexavar and Votrient. I hope your Husband is able to participate in the trial and I pray he does well also. I posted about this trial on 11-02-11. Please let me know if you have any questions.
God Be with You and your Husband,
by Lloyd on Fri Nov 11, 2011 01:16 PM
Got my first infusion Oct 26 and scheduled for the next on Nov 16th. Have had no side effects at all which is great but I'm wondering if I'm on the low dosage for the trial.
Great news about the shrinkgae of your Mothers tumors. I get my first CAT scans Dec 7th and hope for simular results. I'll keep in touch.
by solovemymom on Wed Nov 16, 2011 10:30 PM
Lloyd, Thanks for your reply ! I'm very happy to hear you haven't had any side effects ! My Mom also wondered if she was on the low dosage because she feels so good. However don't worry even if you are on the low dosage because someone told us that there have been patients on even lower doses than included this study and they have responded to the drug too with great results ! Also, there was a reply on Nov 10 to my post about this clinical trial by Lenswife and her husband is doing great on this trial too ! I'm praying for great results with your Dec 7 CAT scan !
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