hi, just to update you on my dads situation, he was diagnosed in November last year with advanced HCC primary liver cancer and given several months. due to the fact that he was in otherwise very good shape he was an excellent candidate for the above trial and although we dont know which drug he is on.. after a year of acute weightloss, side effects and hospital stays he has now been put on much lower dose and he is feeling great. he is eating well, (but still cant put weight back on) having a good quality of life, the lesions all through the year stopped growing and now for the first time he has been told that the lesions are shrinking. he will be on this trial forever as its continual. he has done away with his type 2 diabetes meds, is on no pain killers and only needs a small nap in the afternoon. its been a long year but its doing its job and we are so grateful. he continues with check ups every three weeks and CT scans every six weeks to measure the lesions... but it seems that when they get the dose right so that your body can cope with it, it does make a huge difference. i just wanted to share this news with anyone who may have a similar situation... im having another christmas with my dad and thats got to be positive news for someone else out there.