Women who don't have BRCA mutations could have other high-risk genes that affect treatment choices
by Blessed4life on Fri Oct 20, 2006 12:00 AM
by Pioneer on Fri Nov 10, 2006 12:00 AM
by Johnjr on Sun Nov 12, 2006 12:00 AM
by Gaylec on Fri Nov 17, 2006 12:00 AM
by winningteam2 on Wed Nov 29, 2006 12:00 AM
by Manfred on Mon Jan 08, 2007 12:00 AM
On 8/23/2005 Cidorov wrote:Research published by Dr. Sontheimer from the University of Alabama. This med already fda approved for Chrones and Rheumatoid arthritis showed tumor halt or reversal in imunosupressed human glioma induced rats after 48 hours. My wife was diagnosed and had 5cm by 5cm resection in june. Is now in fourth week of radiation and temodur. Started sulfasalazine three weeks ago. up to 3.5 grams a day and will increase to 4 grams as tollerated. Sulfasalazine bypasses the blood brain barrier and suppresses "system X" which produces death in normal healthy tissue and manufactures a substance that protects the gbm from normal cell death or harm from free radicals. Radiation produces a temporary state of high free radicals to induce chromosomal damage to interfere with replication. The rats in this study just got sulfasalazine. we are hoping the combined effect will be dynamic. Anyone wanting to know more can google sulfasalazine and glioblastoma. I have been coresponding with Dr. Sontheimer and they are looking at a dose of 4-6 grams a day over 3-4 dosings per day. We wont have any imaging until 2-4 weeks after the 6 week course of radiation and temodur. Oncologist says they can't get a good picture while radiation is ongoing. I will repost developements here.
Have you had any success with Sulfalazine? I have GBM stage IV and it looks promising but I have not heard any success stories.
Your response is greatly appreciated!
by Klmot on Tue Jan 09, 2007 12:00 AM
On 8/31/2006 Gennie wrote:My husband was diagnosed almost 4 years ago with this dreadful disease. He has been clear for 3 years until the recurrence last 11/05. He is now taking Avastin which is not yet FDA approved. We will know in October if this is working for him. For those who want to have Avastin for Glioblastoma, ask your oncologist to enroll in SPOC program where they will cover expense if the insurance rejects it.
wanted to see how your husband was doing? I lost my mother to this disease 4 years ago and she was amazing through it all!
by Daniellek on Fri Jan 19, 2007 12:00 AM
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