Probability of precancerous cells turning into cancer??????

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Probability of precancerous cells turning into cancer??????

by Musicnluv79 on Fri Jan 06, 2012 03:16 PM

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Hello everyone. My name is stephanie and im 32 years old. I just recently had an endoscopy done about a week ago due to months of nausea and vomiting and pain and weight loss. My doctor had taken a couple biopsies and told me at the end of the procedure that i had too much bile in my stomach and that my ampulla of vater looked a little suspicious. I did have my gallbladder out when i was 24. So anyway he had called me when the results came back and said that one of the biopsies had come back with abnormal cells and that they are precancerous. He told me he wanted to do another endoscopy in a year and he felt like my nausea was coming from the medications i am on. I went off medications and am still having nausea and im not eating as much as i used to. I get full very fast and im losing more weight. I have read quite a few threads on here and im starting to think that i should be taking this diagnosis more seriously. I want to know how fast can precancerous cells turn into cancer. I want a second opinion but when i called Dana Faber they said they dont think they can help me because it isnt cancer yet. I need advice as soon as possible. Im feeling confused and i dont know what my next steps should be.

RE: Probability of precancerous cells turning into cancer??????

by Serpy on Fri Jan 06, 2012 03:32 PM

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On Jan 06, 2012 3:16 PM Musicnluv79 wrote:

Hello everyone. My name is stephanie and im 32 years old. I just recently had an endoscopy done about a week ago due to months of nausea and vomiting and pain and weight loss. My doctor had taken a couple biopsies and told me at the end of the procedure that i had too much bile in my stomach and that my ampulla of vater looked a little suspicious. I did have my gallbladder out when i was 24. So anyway he had called me when the results came back and said that one of the biopsies had come back with abnormal cells and that they are precancerous. He told me he wanted to do another endoscopy in a year and he felt like my nausea was coming from the medications i am on. I went off medications and am still having nausea and im not eating as much as i used to. I get full very fast and im losing more weight. I have read quite a few threads on here and im starting to think that i should be taking this diagnosis more seriously. I want to know how fast can precancerous cells turn into cancer. I want a second opinion but when i called Dana Faber they said they dont think they can help me because it isnt cancer yet. I need advice as soon as possible. Im feeling confused and i dont know what my next steps should be.

Hi Musicnluv, I am sorry that you are going through this.  I am replying because Dr. Oz just had a show on yesterday about this very topic.  I am going to post a link to it for you to read/view video, hope it works.  Plus, I would go for a 2nd opinion.  Blessings to you. 

http://www.doctoroz.com/videos/stomach-cancer-are-you-risk

RE: Probability of precancerous cells turning into cancer??????

by Musicnluv79 on Fri Jan 06, 2012 03:42 PM

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Thank you Serpy for the link. I had just watched this show yesterday and gave me some insightful information. Unfortunately it seems the odds are coming against me as breast cancer runs in my family and all I did was eat bad foods and I used to smoke. I would love to know if you have gone thru this and what your outcome was. I see a lot of posts about having a diagnosis of cancer but It would help to hear from someone who started out similar to me. Thank you for the blessings.

RE: Probability of precancerous cells turning into cancer??????

by Serpy on Fri Jan 06, 2012 03:50 PM

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On Jan 06, 2012 3:42 PM Musicnluv79 wrote:

Thank you Serpy for the link. I had just watched this show yesterday and gave me some insightful information. Unfortunately it seems the odds are coming against me as breast cancer runs in my family and all I did was eat bad foods and I used to smoke. I would love to know if you have gone thru this and what your outcome was. I see a lot of posts about having a diagnosis of cancer but It would help to hear from someone who started out similar to me. Thank you for the blessings.

Stephanie I am a newbie and caregiver to my mom who was diagnosed with stage 4 lung cancer.  I just happened to see your post and wanted to provide some info that I saw yesterday.  Do go for that 2nd opinion, it couldn't hurt.

RE: Probability of precancerous cells turning into cancer??????

by Musicnluv79 on Fri Jan 06, 2012 03:58 PM

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On Jan 06, 2012 3:50 PM Serpy wrote:

On Jan 06, 2012 3:42 PM Musicnluv79 wrote:

Thank you Serpy for the link. I had just watched this show yesterday and gave me some insightful information. Unfortunately it seems the odds are coming against me as breast cancer runs in my family and all I did was eat bad foods and I used to smoke. I would love to know if you have gone thru this and what your outcome was. I see a lot of posts about having a diagnosis of cancer but It would help to hear from someone who started out similar to me. Thank you for the blessings.

Stephanie I am a newbie and caregiver to my mom who was diagnosed with stage 4 lung cancer.  I just happened to see your post and wanted to provide some info that I saw yesterday.  Do go for that 2nd opinion, it couldn't hurt.

I am very sorry to hear about your mom. I will send prayers her way. I'm a newbie as well. Thank you so much for the link. I'm sure you will find plenty of support on this page. I will definitely be going for the second opinion. Thanks so much :)

RE: Probability of precancerous cells turning into cancer??????

by gastro1 on Fri Jan 06, 2012 07:19 PM

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Well, our situations are VERY similar.  I had lots of gastro problems so in 2006 my doctor sent me to a gastroenterologist for a colonoscopy. While talking to the GI, I mentioned a gluten intolerance, so he said he'd do an upper endoscopy at the same time.  They found a suspicious ampulla of vater--it was much larger than it should have been.  The results were inconclusive, the cells were definitely abnormal, but not quite precancer.  In the end, the GI decided not to do anything.

My primary care doctor sent me back for another biopsy in 2008.  The cells were determined to be precancer.  So in 2 years, with the cells already abnormal, they were still only precancer.  However, once it turned definitely precancer they decided to do surgery.

The surgeon told me there were two types of surgery he could do.  A small bowel resection or a Whipple and he wouldn't know which to do until he got in there.  He ended up doing the small bowel resection which consisted of removing the tumor and the area around it, and then rerouting the bile and pancreatic ducts.

I've had a couple of followup biopsies which had been clear until my last one in February of 2011.  The pathology report initially came back precancer, but my doctor asked them to review again and compare to all my past slides.  In the end they amended their report to say it might not quite be precancer.  The GI put me on a 1 year call back.

I've made my appointment with him to set up the scope, so I'll know the outcome in a few weeks.  I do know that if it comes back precancer they will do the Whipple.  The surgeon had already warned me about this and it corresponded with what I'd read on various medical sites.

I'm sorry that was so long winded, but if you're like me you're looking for any kind of info, and when I was looking for it in 2006, there wasn't a lot around.  I think generally the tumors in this area are slow growing, but I am a little surprised with a definite precancer report they are waiting a full year.

RE: Probability of precancerous cells turning into cancer??????

by Musicnluv79 on Fri Jan 06, 2012 07:53 PM

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On Jan 06, 2012 7:19 PM gastro1 wrote:

Well, our situations are VERY similar.  I had lots of gastro problems so in 2006 my doctor sent me to a gastroenterologist for a colonoscopy. While talking to the GI, I mentioned a gluten intolerance, so he said he'd do an upper endoscopy at the same time.  They found a suspicious ampulla of vater--it was much larger than it should have been.  The results were inconclusive, the cells were definitely abnormal, but not quite precancer.  In the end, the GI decided not to do anything.

My primary care doctor sent me back for another biopsy in 2008.  The cells were determined to be precancer.  So in 2 years, with the cells already abnormal, they were still only precancer.  However, once it turned definitely precancer they decided to do surgery.

The surgeon told me there were two types of surgery he could do.  A small bowel resection or a Whipple and he wouldn't know which to do until he got in there.  He ended up doing the small bowel resection which consisted of removing the tumor and the area around it, and then rerouting the bile and pancreatic ducts.

I've had a couple of followup biopsies which had been clear until my last one in February of 2011.  The pathology report initially came back precancer, but my doctor asked them to review again and compare to all my past slides.  In the end they amended their report to say it might not quite be precancer.  The GI put me on a 1 year call back.

I've made my appointment with him to set up the scope, so I'll know the outcome in a few weeks.  I do know that if it comes back precancer they will do the Whipple.  The surgeon had already warned me about this and it corresponded with what I'd read on various medical sites.

I'm sorry that was so long winded, but if you're like me you're looking for any kind of info, and when I was looking for it in 2006, there wasn't a lot around.  I think generally the tumors in this area are slow growing, but I am a little surprised with a definite precancer report they are waiting a full year.

Gastro1 thank you so much foretelling me your story. It's helped me a lot to make a decision. I was back and forth with the second opinion. I started to think maybe I was over reacting to the diagnosis but I now know I need a second opinion. I hope in your situation your biopsy comes back fine. If you do end up having the surgery I would like to know your experience. I'm still a little unsure about who I should contact for a second opinion but Ill keep researching and I'm sure I'll figure it out. Once again thank you so much for sharing your story with me.

RE: Probability of precancerous cells turning into cancer??????

by gastro1 on Fri Jan 06, 2012 08:25 PM

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I wish you good luck in finding that second opinion.

 

RE: Probability of precancerous cells turning into cancer??????

by Musicnluv79 on Sat Jan 14, 2012 07:42 PM

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Well I just had a meeting with my GI to ask some questions and to see if this is serious. He told me this is nothing to worry about. It was only a small area which was precancerous. The lab results were a focal adenoma. He said we would just wait and do another test in a year. I'm still not sure if I should wait a year. I still haven't made an appt for a second opinion yet. I wish someone else here had the same diagnosis as me and I would love to know their course of action and what happened. My gastro didn't tell me anything about a resection at all.

RE: Probability of precancerous cells turning into cancer??????

by Whippleschmiple on Sun Jan 15, 2012 09:08 PM

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Stephanie,

  I  had sent you a private message but I am not sure you ever got it.  In general I had a pylorus preserving whipple for a small mass of which part was benign adenoma and part was malignant which triggered 13 biopsies, whole mass was small and NOT visible on any type of ultrasound, cat scan or mri.  Of note, sometimes people are told it is an ampullary adenoma and there are unbiopsied areas that are malignant (false negatives).  These cancers can get aggressive fast, which means adenoma may go malignant fast too.  From what I know now, I would be at the very least getting an ampullectomy at a top national cancer institute center from a doc and facility that know ampullary and pancreatic cancers and see many cases of ampullary per year (minimum maybe around 8-12, 12 ++ preferable).  Even CTCA in Penn. saw far less than that so I would not have gone there.

I would get a top center second opinion fast, first asking how many cases of ampullary seen/yr, number of whipples done (just in case) and that should some doc there doing over 100 in 1-2 years.  I was told if it was benign then ampullectomy,  if malignant, pylorus preserving whipple and I suspect most of these start as adenomas, mine did.  I was also told even though mine was stage 1B, very small, that if it hadn't been found and removed I would have been agoner in 6-12 mos which shows the potential speed of these and I am far younger than the average age of 70 with these.  Different centers also have the ability to diagnose biopsies better than others.  I know from a chart even stage zero ampullary from the only chart of about 5500 patients showed 49% recurrence, which is likely due to undertreating and ampullectomy when most then should have whipple.  These are sneaky and can be quite aggressive.  Get the top second opinion asap, remove it, don't just watch it, but YOUR choice (after second top opinion) and if ampullectomy and any malignancy, unless maybe well-differentiated and under 1 cm and no risk features, risk too high then to not do whipple and even then high rate recurrence if undertreat.  I had my whipple 1 1/2 yrs ago.  Even my top NCI center doc gladly sent me for a second opinion and based on the second we decided and they agreed to more treatment to reduce risk of recurrence.  J in NH

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