Small trial suggests the scans might help, but experts aren't so sure
by cdolive4 on Mon Jan 30, 2012 10:19 PM
by Cristiana on Mon Jan 30, 2012 10:46 PM
I do not know about Delta 24 but overheard doctors saying that inject drugs ( in this case was Avastin ) directly in the tumor is no good.
I have tried to call attention to BSI 201 still a trial, phase 2 .It is a nuclear enzyme that acts repairing DNA . It has no side effects, very well tolerated.
Tha cases I know of are two GBM patients with no recurrence , one after 18 months of surgery and another after more than 24 months of surgery.
I wish all the luck to us all suferring from such a monstruous disease
by huxley2006 on Tue Jan 31, 2012 11:02 AM
Why not try a vaccine? If its not offered at your facility try UCLA or some of the other facilties. ICT-107. DC-Vax or the standard Dendrite Cell Vaccines. All show a lot of promise. IF your husband is healthy, nothing wrong with traveling to a different facility. I am Sure MD will work with the facility of your choice. If I suffer another recurrence this would be the first option I would explore. It’s one of the few clinicals out there that have a great deal of published information. For the most part information published is positive
by siblingof on Tue Jan 31, 2012 02:02 PM
by siblingof on Tue Jan 31, 2012 02:08 PM
by GBMhubby on Tue Jan 31, 2012 08:15 PM
As for trial recommendation, one never knows the potential merit of a phase 1 or phase 2 trial. My approach has been to look at the most recently initiated trials, say in the past year, because those are more likely to reflect the latest thinking and research findings. (The delta-24 trial is listed as starting in 2008.) And I would save any trial that used Avastin (bevacizumab) until last use, because prior use of Avastin is a rule-out in a number of trials.
MD Anderson appears to list 5 recurrent glioblastoma trials that meet the criteria outlined above (Ref: clinicaltrials.gov ).
by HelperM on Tue Jan 31, 2012 11:24 PM
I read the protocol and it looks like very much of an individual decision. There are a lot of clinical trials out there, and especially with a phase one trial it's hard to know if it might be effective. Here's a technical article on the subject http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935304/ II a lot to plow through but gives a better idea of what they have done so far.
by HelperM on Tue Jan 31, 2012 11:27 PM
I see the link got missed up. Here's the correct one http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935304/
by Cristiana on Wed Feb 01, 2012 01:04 AM
Hi the BSI 201 is a phase 2 but it appears to be what makes the most sense nowadays, because if it can really repair DNA it can make bad cells die.
Please take a quick look on it. Temodar once was a phase 1 and 2 trial ....
Wonderful week for all
by huxley2006 on Wed Feb 01, 2012 08:38 PM
I have tried to find published PFS and OS info for parp inhibitors as it relates to Brain Cancer and have not been able to locate much information. Do any of you have this information?
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