Possible recurrent GBM - Delta 24 clinical trial

Hi to all, and peace and blessings to each of you. My husband, Dave, was diagnosed with GBM last March. It was resected, he underwent the standard treatment at MD Anderson, and then had a second surgery in August for what they thought was recurrent tumor but was necrosis, with NO sign of any tumor cells. Last week's MRI showed a possibility of recurrence vs. necrosis again, but of course, there's no way to know for sure unless they go in and look. MD Anderson is recommending a phase one clinical trial for Delta 24, an adenovirus which they would inject directly into the tumor. Is anyone familiar with this protocol? Or does anyone, including GBMhubby, have any suggestions for recurrent tumor? Dave is in excellent overall physical and mental health, and is 51. We have a few weeks to gather information and would welcome any input. Thanks, Cindy

Dear Cindy

I do not know about Delta 24 but overheard doctors saying that inject drugs ( in this case was Avastin )  directly in the tumor is no good.

I have tried to call attention to BSI 201 still a trial, phase 2 .It is a nuclear enzyme that acts repairing DNA . It has no side effects, very well tolerated.

Tha cases I know of are two GBM patients with no recurrence , one after 18 months of surgery and another after more than 24 months of surgery. 

I wish all the luck to us all suferring from such a monstruous disease

Cris

Why not try a vaccine?  If its not offered at your facility try UCLA or some of the other facilties. ICT-107. DC-Vax or the standard Dendrite Cell Vaccines. All show a lot of promise. IF your husband is healthy, nothing wrong with traveling to a different facility. I am Sure MD will work with the facility of your choice. If I suffer another recurrence this would be the first option I would explore. It’s one of the few clinicals out there that have a great deal of published information. For the most part information published is positive

Hux

 

 

I guess my first question would be why are they recommending a Phase I trial, when he's still doing well? Our N-O told us to avoid anything below Phase II.

I don't know why my message disappeared, but I'll repeat it-- why do a Phase 1 trial if he's doing well? And I agree that the vaccines seem very promising. Also, what specific genetic characteristics does your husband's tumor exhibit and is this Delta 24 adenovirus believed to be effective against those characteristics?

As for trial recommendation, one never knows the potential merit of a phase 1 or phase 2 trial.  My approach has been to look at the most recently initiated trials, say in the past year, because those are more likely to reflect the latest thinking and research findings.  (The delta-24 trial is listed as starting in 2008.)  And I would save any trial that used Avastin (bevacizumab) until last use, because prior use of Avastin is a rule-out in a number of trials.

MD Anderson appears to list 5 recurrent glioblastoma trials that meet the criteria outlined above (Ref: clinicaltrials.gov ).

I read the protocol and it looks like very much of an individual decision.  There are a lot of clinical trials out there, and especially with a phase one trial it's hard to know if it might be effective.  Here's a technical article on the subject http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935304/ II a lot to plow through but gives a better idea of what they have done so far.  

I see the link got missed up.  Here's the correct one http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935304/

Hi the BSI 201 is a phase 2 but it appears to be what makes the most sense nowadays, because if it can really repair DNA it can make bad cells die.

Please take a quick look on it. Temodar once was a phase 1 and 2 trial ....

Wonderful week for all

Cris

I have tried to find published PFS and OS info for parp inhibitors as it relates to Brain Cancer and have not been able to locate much information. Do any of you have this information?

 

Hux