New study out on Oligo's w/ co-deletions

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New study out on Oligo's w/ co-deletions

by karynk on Fri Feb 03, 2012 05:12 PM

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http://www.nih.gov/news/health/jan2012/nci-19.htm

Some impressive numbers in this one.

 

RE: New study out on Oligo's w/ co-deletions

by dmercer on Fri Feb 03, 2012 07:07 PM

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Either the radiation makes the chemo more powerful or the chemo makes the radiation more powerful. I guess it depends on whether you're a radio-oncologist or a neuro-oncologist. :) I'm curious to see the results of a recent large study on recurrent grade 2s that go through this protocol. This is what I have and did. I'm affraid it won't be for a while though. Hopefully by then they'll be a cure and none of us will care anyway. This story does give us hope.

Grace and Peace,

Danny

RE: New study out on Oligo's w/ co-deletions

by MsRoxy on Sat Feb 04, 2012 02:38 AM

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On Feb 03, 2012 7:07 PM dmercer wrote:

Either the radiation makes the chemo more powerful or the chemo makes the radiation more powerful. I guess it depends on whether you're a radio-oncologist or a neuro-oncologist. :) I'm curious to see the results of a recent large study on recurrent grade 2s that go through this protocol. This is what I have and did. I'm affraid it won't be for a while though. Hopefully by then they'll be a cure and none of us will care anyway. This story does give us hope.

Grace and Peace,

Danny

Grace and Peace...how lovely how very lovely...I will use that now...it is my gift from you. xoxox Roxy

RE: New study out on Oligo's w/ co-deletions

by karynk on Sat Feb 04, 2012 12:13 PM

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Yes - this study does give us hope.

The one thing I really do not understand, is why the studies for Oligos (and mixed tumors) almost always use PCV chemo, but yet almost everyone (including my husband) that I have read about thru this site has been put on Temodar.  I know, from everything that I have read over the years, that PCV is a harsh treatment with diet restrictions. 

Karyn

RE: New study out on Oligo's w/ co-deletions

by dmercer on Sun Feb 05, 2012 12:28 AM

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They used PCV because they were started before tmz was the standard of care. The newer studies use tmz. Grace and peace, Danny

RE: New study out on Oligo's w/ co-deletions

by GBMhubby on Sun Feb 05, 2012 04:02 AM

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On Feb 04, 2012 12:13 PM karynk wrote:

Yes - this study does give us hope.

The one thing I really do not understand, is why the studies for Oligos (and mixed tumors) almost always use PCV chemo, but yet almost everyone (including my husband) that I have read about thru this site has been put on Temodar.  I know, from everything that I have read over the years, that PCV is a harsh treatment with diet restrictions. 

Karyn

Concerning PCV vs Temodar for Oligo's, there is some indication that PCV may provide a longer progression free time, which has to be balanced by consideration of higher toxicity.

From this multi-institutional publication in 2011:

Title: "International retrospective study of over 1000 adults with anaplastic oligodendroglial tumors" 

"Subject to the limitations of study design, our data suggest that initial treatment with chemotherapy alone may be a reasonable option for patients with 1p19q codeleted tumors, and PCV appears to offer longer disease control than temozolomide but with greater known toxicity and without a clear prolongation of survival."

"TMZ has largely replaced PCV in the treatment of gliomas. Surprisingly, our data demonstrated that PCV alone afforded better disease control than TMZ alone in 1p19q codeleted cases, with median time-to-progression longer by more than 4 years, a medically and statistically significant difference despite the small sample size for each group. Recent results also suggest that responses of low grade oligodendrogliomas to PCV are more durable than with TMZ,"

The study report can be found here:

http://neurooncology.ucla.edu/pub/06132011.pdf

RE: New study out on Oligo's w/ co-deletions

by karynk on Sun Feb 05, 2012 12:13 PM

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GBMHubby -

Thank you so much for posting this link! 

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