Granulosa cell tumors - recurrent

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Granulosa cell tumors - recurrent

by StarryJones on Sun Mar 11, 2012 07:49 PM

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I was very happy to find this forum as this is the first time I've heard of anyone who has the same type of tumor.  I only learned this week that this is a type of ovarian cancer and I've had this disease for 11 years!

My first experience (which sounds like so many others) was with a rather sudden, pretty excruciating, abdominal pain that eased up after a few hours.  My OB/GYN told me it was a ruptured ovarian cyst. Nothing more was done.  Then over the course of the next couple of years this happened at least 2 more times and each time getting much worse - pain lasting longer, not able to stand up for the dizziness and taking several days to ease up.  It must have been the 3rd time that the pain would not go away and radiated all over my abdoment.  I was sent for an abdominal ultrasound and first heard that word, "Mass".  Pretty scarey!  So surgery was less than a week later - total abdominal hysterectomy and bilateral oopherectomy and general clean up from the ruptured cystic tumor.  I was floored 10 days later when I was told that the histology was questionable for small cell cancer or granulosa cell cancer so it was sent to Cambridge for a 2nd opinion.  The verdict came back granulosa cell and I breathed a big sigh of relief and merrily went on my way.  When I came back for follow-up I was told the tumor can come back and that there was a blood test that could track it...very expensive but I was advised to get it done at least every 6 months.

Shortly after this we discovered my husband had end stage liver disease due to Hep C and we had to uproot, return to the US and start the process of being evaluated for liver transplant.  Needless to say, with all the ups and downs with that process, my own health concerns not only took a back burner but were shoved out of the kitchen entirely!!  Then came an episode....maybe 6 months after his transplant...when again I had this funny, escalating abdominal pain - this time more epigastric in region - and I had NO clue what it could be.  I left work and barely made it to an Urgent Care facility....where they happily decided that it must be a kidney stone!  They did no testing to confirm or deny this.  A month later I went to my GP and mentioned the episode and my concerns and she ordered a CT of the abdomen (without contrast) that showed nothing!

A year later I finally decided to repeat my blood test for Serum Inhibin A and it was up!  My doctor now wanted an urgent CT - with and without contrast - and there was the grapefruit sized tumor!  The radiologist went so far as to say that comparing it to the previous year, they could see the tumor was present then!!  At this point I was linked up with a wonderful Gyne Oncologist who did my surgery, (five years after my previous surgery) removing multiple tumors and about 5 inches of my colon.   This doctor insisted on compliance with quarterly blood tests of both the Inhibin A and B.

I have just returned from having my 3rd surgery - this about 5 years after the previous in 2006.  This time there was new technology - the Da Vinci system - so she was able to do the surgery robotically and was able to spot and remove tumors that were smaller that what she would have been able to see with the naked eye.  The recovery is going much better than the open surgery and I was back to work less than 3 weeks after surgery (although I would NOT recommend that to others - would wait at least 4 weeks!)

We are continuing on the conservative treatment - monitoring the Serum Inhibins A & B every 3 months and I personally am following the alkalizing diet, no meat, no dairy and looking into the wheat grass thing.  Being a nurse, a patient and former researcher...I am determined that we, as a group, can help find....if not a total cure..then at least a way to stave off these recurrences for as long as possible!

RE: Granulosa cell tumors - recurrent

by sophiedecorte on Thu Mar 15, 2012 02:35 PM

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On mrt 11, 2012 7:49 StarryJones wrote:

I was very happy to find this forum as this is the first time I've heard of anyone who has the same type of tumor.  I only learned this week that this is a type of ovarian cancer and I've had this disease for 11 years!

My first experience (which sounds like so many others) was with a rather sudden, pretty excruciating, abdominal pain that eased up after a few hours.  My OB/GYN told me it was a ruptured ovarian cyst. Nothing more was done.  Then over the course of the next couple of years this happened at least 2 more times and each time getting much worse - pain lasting longer, not able to stand up for the dizziness and taking several days to ease up.  It must have been the 3rd time that the pain would not go away and radiated all over my abdoment.  I was sent for an abdominal ultrasound and first heard that word, "Mass".  Pretty scarey!  So surgery was less than a week later - total abdominal hysterectomy and bilateral oopherectomy and general clean up from the ruptured cystic tumor.  I was floored 10 days later when I was told that the histology was questionable for small cell cancer or granulosa cell cancer so it was sent to Cambridge for a 2nd opinion.  The verdict came back granulosa cell and I breathed a big sigh of relief and merrily went on my way.  When I came back for follow-up I was told the tumor can come back and that there was a blood test that could track it...very expensive but I was advised to get it done at least every 6 months.

Shortly after this we discovered my husband had end stage liver disease due to Hep C and we had to uproot, return to the US and start the process of being evaluated for liver transplant.  Needless to say, with all the ups and downs with that process, my own health concerns not only took a back burner but were shoved out of the kitchen entirely!!  Then came an episode....maybe 6 months after his transplant...when again I had this funny, escalating abdominal pain - this time more epigastric in region - and I had NO clue what it could be.  I left work and barely made it to an Urgent Care facility....where they happily decided that it must be a kidney stone!  They did no testing to confirm or deny this.  A month later I went to my GP and mentioned the episode and my concerns and she ordered a CT of the abdomen (without contrast) that showed nothing!

A year later I finally decided to repeat my blood test for Serum Inhibin A and it was up!  My doctor now wanted an urgent CT - with and without contrast - and there was the grapefruit sized tumor!  The radiologist went so far as to say that comparing it to the previous year, they could see the tumor was present then!!  At this point I was linked up with a wonderful Gyne Oncologist who did my surgery, (five years after my previous surgery) removing multiple tumors and about 5 inches of my colon.   This doctor insisted on compliance with quarterly blood tests of both the Inhibin A and B.

I have just returned from having my 3rd surgery - this about 5 years after the previous in 2006.  This time there was new technology - the Da Vinci system - so she was able to do the surgery robotically and was able to spot and remove tumors that were smaller that what she would have been able to see with the naked eye.  The recovery is going much better than the open surgery and I was back to work less than 3 weeks after surgery (although I would NOT recommend that to others - would wait at least 4 weeks!)

We are continuing on the conservative treatment - monitoring the Serum Inhibins A & B every 3 months and I personally am following the alkalizing diet, no meat, no dairy and looking into the wheat grass thing.  Being a nurse, a patient and former researcher...I am determined that we, as a group, can help find....if not a total cure..then at least a way to stave off these recurrences for as long as possible!

Hello

my name is Sophie from Belgium. I am 42 years old and had already 3 surgeries. the last one in september 2011 where the granulosa tumour was behind the spleen. Before in januari 2010 they removed 5 granulosa tumours all over the place, even one on the abdominal wall where the incision had been done during my first surgery in 2001. In 2002 after surgery I have had chemo for 6 months but it came back. so I am really relunctant on chemo; DOES IT WORK for granulosa tumours??

Now with the last scan they discovered suspicious lesions of 9 mm and one smaller in the area of my bowls. again the docter advise surgery and even chemo;

I am desperate to get more information about this disease. can anyone help me to tell me the good news?

Thank you so much

Sophie

RE: Granulosa cell tumors - recurrent

by StarryJones on Thu Mar 15, 2012 03:50 PM

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Hi Sophie, I hear your desperation and frustration! From what I understand, chemo does not work for these tumors! I also understand that in certain cases if the disease has progressed with many, many tumors, or if the person is very young ...like in their 20's..the disease seems to be more aggressive in the young...then they might try chemo. But for the most part it is known that it does not help. There are studies going on that use Lupron or Avastin...maybe you and your doctor could look into that. For me, my doctor does a blood test called serum inhibin A and B, every 3 months. When the markers go up (usually the B goes up first) then we know the tumors are back. At that point I get a CT scan and if they see the tumors, they operate to remove and while there, look all around for other tumors. Meanwhile, I have given up meat and dairy, am following an alkali zing diet and eating lots of fresh fruit and vegetables. So...surgery Yes, chemo No....unless you have consulted some specialist in the field with lots of experience with granulosa cell tumor! Hang in there!!

RE: Granulosa cell tumors - recurrent

by teblevins on Fri Mar 23, 2012 01:29 AM

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Hi StarryJones and Sophie... I too have been diagnosed with GCT. I notice in reading the postings that inhibin A and B are the markers for this cancer. How high does the inhibin B have to be before the cancer can be seen by CT scan? My inhibin B has been elevating since Dec 2011 but my Dr. says it will not do any good at this point for a CT scan.  I don't understand.

Even though this is cancer, I am so glad to read the postings. I have been researching this cancer for a while now. There basically isn't much out there to find. However, I have asked GCT Research Foundation about a possible cause.  Many have said that having this type of cancer is just bad luck, but I honestly believe there something that has caused it and we will eventually figure it out.

I keep you all in my prayers.

TB in GA

RE: Granulosa cell tumors - recurrent

by sophiedecorte on Fri Mar 23, 2012 08:00 AM

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On mrt 23, 2012 1:29 teblevins wrote:

Hi StarryJones and Sophie... I too have been diagnosed with GCT. I notice in reading the postings that inhibin A and B are the markers for this cancer. How high does the inhibin B have to be before the cancer can be seen by CT scan? My inhibin B has been elevating since Dec 2011 but my Dr. says it will not do any good at this point for a CT scan.  I don't understand.

Even though this is cancer, I am so glad to read the postings. I have been researching this cancer for a while now. There basically isn't much out there to find. However, I have asked GCT Research Foundation about a possible cause.  Many have said that having this type of cancer is just bad luck, but I honestly believe there something that has caused it and we will eventually figure it out.

I keep you all in my prayers.

TB in GA

Hello

glad to meet you. I have had a scan and my blood test on inhibin B was normal but on the scan there are 2 lesions again one of 9 mm and one smaller in the area of my small intestins.

bad luck, yes, but it is definately a mistake in dna. For some reason this dna is reproducing these tumors and producing oestrogel too.

NOW i am on PROVERA , which is the counter hormone of oestrogel, called progesteron

my professor who is studying this tumour said that i need a new surgery, to remove these lesions and he wants to see in me to see for other small lesions. Afterwards he advised chemo therapy BEP but I have read it does not work

The docter told me that one patient with the same granulosa tumor was during 15 years free of these tumors, .

Unfortunately it is a rare cancer and not a lot of research is being done, so my prayers is going to that super docter who will find a cure for it. let's pray together to get cleaned. We all deserve to life!

my operation is planned for the 2nd of April. Wish me good luck

all the best and lots of love to you all.

Sophie

 

RE: Granulosa cell tumors - recurrent

by StarryJones on Mon Mar 26, 2012 01:00 AM

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Hi TB in GA,

You asked a question about the Inhibin A & B and the relationship to seeing tumor on CT.  I would bet that we each might be different but it sure would be nice to think that our collective information could be of help to each other.  My Inhibin B was elevating for at least 10 months before they were able to see a tumor on CT scan.  When they operated about 7 weeks later, there were actually 2 tumors the same size (about golf ball) and another 4 microscopic ones.  I believe my Inhibin B was about 90 and my Inhibin A was about 4.  Do you know what your levels are?  For me it seems that the B goes up first - the A might only go up after a tumor ruptures....which hopefully won't happen again!  When was your last surgery?  

Good Luck and please stay in touch!!

RE: Granulosa cell tumors - recurrent

by StarryJones on Mon Mar 26, 2012 01:06 AM

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Hi Sophie,

How long have you known that you had Granulosa cell cancer?  And if you don't mind my asking, how old are you?  When was your last surgery?  From my reading, it seems that the younger women have a more aggressive form of this disease and maybe that is why it is treated more aggressively.  For me, I am 63 now and first learned about this when I was about 51.  I have had 3 surgeries now going about 5 years in between them.  I am not on any medication and fortunately my doctor did not recommend chemo.  I have heard about the Provera type treatments and that they are showing some success.  I hope I hear back from you before your upcoming surgery and again, after your surgery.  Good Luck!!  Hang in there and maybe together we will all help this science!

RE: Granulosa cell tumors - recurrent

by sophiedecorte on Mon Mar 26, 2012 04:08 AM

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On mrt 26, 2012 1:06 StarryJones wrote:

Hi Sophie,

How long have you known that you had Granulosa cell cancer?  And if you don't mind my asking, how old are you?  When was your last surgery?  From my reading, it seems that the younger women have a more aggressive form of this disease and maybe that is why it is treated more aggressively.  For me, I am 63 now and first learned about this when I was about 51.  I have had 3 surgeries now going about 5 years in between them.  I am not on any medication and fortunately my doctor did not recommend chemo.  I have heard about the Provera type treatments and that they are showing some success.  I hope I hear back from you before your upcoming surgery and again, after your surgery.  Good Luck!!  Hang in there and maybe together we will all help this science!

i have this since 2001. I was 31 years old.

Now I am 42

my last surgery was in september 2011.

Why did your doctor not recommend chemo? this is very important to know.

I am on provera since my last surgery and the doctor wants me to keep taking them

I cannot sleep anymore, very down to know that it is back already.

Thank you for your reply, it gives me a lotof support and comfort to know i am not the only one.

Big hug,

Sophie

 

RE: Granulosa cell tumors - recurrent

by sophiedecorte on Mon Mar 26, 2012 04:12 AM

Quote | Reply

On mrt 26, 2012 1:00 StarryJones wrote:

Hi TB in GA,

You asked a question about the Inhibin A & B and the relationship to seeing tumor on CT.  I would bet that we each might be different but it sure would be nice to think that our collective information could be of help to each other.  My Inhibin B was elevating for at least 10 months before they were able to see a tumor on CT scan.  When they operated about 7 weeks later, there were actually 2 tumors the same size (about golf ball) and another 4 microscopic ones.  I believe my Inhibin B was about 90 and my Inhibin A was about 4.  Do you know what your levels are?  For me it seems that the B goes up first - the A might only go up after a tumor ruptures....which hopefully won't happen again!  When was your last surgery?  

Good Luck and please stay in touch!!

hi

my inhibin was normal, means no significance level

but the doctor told me that when the tumors are mm you do not see it yet in the blood.

It is like a little bomb in your body, slowly growing but it grows. My spleen had to be removed because it was already attached to it (surgery in sept 2011)

it has to be removed as quick as possible

big hug,

sophie

RE: Granulosa cell tumors - recurrent

by teblevins on Mon Mar 26, 2012 05:38 PM

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Hi StarryJones

Thanks for responding.  I greatly appreciate it. In January 16th 2012 my inhibin B was 8.2 my estrogen level was 159 but I do take HRT Premarin.  My doctor said he is waiting until at least 70 to 100 before he goes looking for it. I am just scared of what will happen to me with this thing inside of me.  The first time was not pleasant and I don't want to be in the middle of something that could be dangerous like driving and I go crazy.  Do you remember how you felt at the time your inhibin was 90? Could you tell a difference in your every day life.  The only thing I can tell right now is that my stomach bothers me all the time. I am bloated constantly so I take Simethicone when I cannot stand it any longer. I feel like I let it take its course but I am not sure if that is good either. Is there anything you can remember about how you felt right before the Dr removed the golf ball tumors?

Thanks again for talking with me.  I am so happy in finding you guys. 

Thanks

TB in GA

 

 

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