glioblastoma (GBM) IV

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glioblastoma (GBM) IV

by jimsbabygirl on Tue May 15, 2012 12:43 AM

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Is this brain tumor hereditary?  After my Dad passed 5 months after he was diagnosed with this, I found out his older brother passed 22+ yrs ago of the same thing and that his middle brother died of a "brain trauma".

RE: glioblastoma (GBM) IV

by jon4156 on Tue May 15, 2012 01:14 AM

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It is not hereditary according to medical science.  Brain trauma could be caused by any blunt force to the head but is not a cancer so doesn't count.

RE: glioblastoma (GBM) IV

by siblingof on Tue May 15, 2012 01:35 PM

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Sorry to hear about your dad. This is still being researched. In fact, there's an ongoing study listed on clinicaltrials.gov which is basically a survey of relatives of two or more GBM patients. For many years, the received wisdom was that GBM was not hereditary-- so much so that an 80-year-old doctor assured me the other day that it couldn't possibly be. However, there have been several case studies published recently... familial glioblastoma seems to be rare but not unheard of. It may be that it is most commonly a genetic condition (such as NF1) that is inherited, which in turn increases the likelihood of GBM. There are several such conditions listed in the wikipedia article on GBM. --("Brain trauma" sounds like a head injury, though, like from an accident.)

RE: glioblastoma (GBM) IV

by kim55 on Fri May 18, 2012 03:16 PM

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Our oncologist who is a brain tumor specialist assured me that glioblastomas are not hereditary.  I certainly hope and pray they arent.  I have 2 precious sons.

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