I've been on Xeloda for 1+ yrs. Worst side is feet. The best thing I've found so far is Kerasal; tried Aquafor, Eucerin, etc. Podatrist gave me a Rx for new product called Neosalus. Comes in different forms, mine is for lotion. Very $$. $232.00 for 8 oz. New product, said it heals from inside out. Not covered by Medicare. Haven't bitten bullet yet to fill Rx. I wear rubber gloves but husband does most of kitchen clean up. I started w/8 500 pills a day, Dr. reduced to 6, on a week off a week, which helped a little. Lubricate feet at least 3 times a day; sometimes more. Sorry can't be more helpful.