the chemo gemzar was very binding for my wife ,she practicly needed a crowbar to go,so I would not be using diarrehah as a measure ---creon replaces the amalyse and lipase -needed to break down food ---they are actualy pig enzymes or some others from plants -if you grand mother is losing weight she may need them -she needs all the weight and strengh she can get ,gastroenteroligist -or a nutritionist that deals with pc patients can advise best ,many drs and oncoligists are not aware of it -since pc is so rare and patients only 10 % that have a whipple surgury rarer as you can see if a dr is advising -the purpose of enzymes is to stop a loose bowel only he is not a specialist in pc - Tom